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tag phage culture

bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
The Ties That Bind: Peptide Display Technology
Debra Swanson | Mar 14, 1999 | 10+ min read
Date: March 15, 1999 Phage Display Systems and Vectors Structure of the T7 phage particle. The negative-stained pattern from polyheads showing capsid hexamer and pentamer units has been fitted onto the surface of the icosahedral particle. A single monomer of the capsid protein is shaded in red. Figure provided by Novagen. Back in the early '50s, at a time when Elvis Presley was beginning his undisputed reign as the king of rock 'n' roll, bacteriophage were rearing their ugly heads (so to spe
Effector detector
Alla Katsnelson | Oct 1, 2008 | 2 min read
Credit: ® CAMR/A. Barry Dowsett / Photo Researchers, Inc." /> Credit: ® CAMR/A. Barry Dowsett / Photo Researchers, Inc. The paper: T. Tobe et al., "An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination," Proc Nat Acad Sci, 103:14941-6, 2006. (Cited in 38 papers.) The study: Some virulent bacteria infec
Bacteria Harbor Geometric “Organelles”
Amber Dance | Dec 1, 2018 | 10+ min read
Microbes, traditionally thought to lack organelles, get a metabolic boost from geometric compartments that act as cauldrons for chemical reactions. Bioengineers are eager to harness the compartments for their own purposes.
Macro, Mini, Micro
Carina Storrs | Jan 1, 2013 | 7 min read
Clever microfluidic platforms take the study of protein-protein interactions to a new level.
An Ocean of Viruses
Joshua S. Weitz and Steven W. Wilhelm | Jul 1, 2013 | 10+ min read
Viruses abound in the world’s oceans, yet researchers are only beginning to understand how they affect life and chemistry from the water’s surface to the sea floor.
Automated Colony Pickers Evolve
Helen Dell(hdell@the-scientist.com) | Jul 3, 2005 | 6 min read
Everyone knows that the first genome sequencing projects took years of work and represent the combined product of tens of thousands of individual fragments.
Honing Your Cloning
Bob Sinclair | Aug 20, 2000 | 8 min read
Early attempts to design vehicles for the cloning of foreign DNA produced vectors that were too big, unstable, or unselectable. The tide turned in 1977 with the construction of pBR313, the direct ancestor of the well-known pBR322, which forms the basis of many vectors that are still used extensively today.1 However, the cloning systems introduced in the last year or so seem to be about as related to pBR313 as Ferraris are to little red Radio Flyer wagons. Some of the new protein expression syst
Thinking Outside the Icebox on DNA Storage
Gail Dutton(gdutton@the-scientist.com) | Jul 17, 2005 | 6 min read
Lab freezers are like mom's attic: cluttered with the property of people long gone.

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