The normal functions of peptides that aggregate in Alzheimer’s, Parkinson’s, and Huntington’s have been largely overlooked by scientists, but some argue that they are critical for understanding the development of disease.
The long noncoding RNA MINCR, implicated in ALS and Alzheimer’s disease as well as several types of cancer, appears to function differently when present at high versus low levels.
By audaciously pursuing an abandoned area of research, Ana María Cuervo discovered how cells selectively break down their waste, and revealed the health consequences when that process malfunctions.