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tag alternative splicing evolution disease medicine

Alternative Splicing Goes Mainstream
Sam Jaffe | Dec 14, 2003 | 10 min read
In eukaryotic genetics, the one-gene/one-protein concept has, for the most part, breathed its last. Researchers have rallied behind mechanisms such as alternative splicing, which may allow a lowly 30,000-gene genome to produce the dizzying variety of proteins that some believe is necessary to produce beings as complex as humans. Alternative splicing--the post-transcriptional editing process that can result in various mRNAs--was previously seen as an interesting but relatively uncommon sidesh
Exploring the alternatives
Tabitha Powledge(tam@nasw.org) | Sep 25, 2003 | 4 min read
Splicing investigators see medical applications and a possible new role in gene expression
Conceptual image showing molecules making up a brain shape
The Noncoding Regulators of the Brain
Christie Wilcox, PhD | Sep 12, 2022 | 10+ min read
Noncoding RNAs are proving to be critical players in the evolution of brain anatomy and cognitive complexity.
Protein Synthesis Enzymes Have Evolved Additional Jobs
Amber Dance | Jun 1, 2020 | 10+ min read
Aminoacyl-tRNA synthetases, which help translate the genetic code into protein, also function in angiogenesis, fat metabolism, and more.
Illustration showing a puzzle piece of DNA being removed
Large Scientific Collaborations Aim to Complete Human Genome
Brianna Chrisman and Jordan Eizenga | Sep 1, 2022 | 10+ min read
Thirty years out from the start of the Human Genome Project, researchers have finally finished sequencing the full 3 billion bases of a person’s genetic code. But even a complete reference genome has its shortcomings.
Cancer’s Escape Routes
Tia Ghose | Nov 29, 2011 | 5 min read
Scientists are beginning to discover myriad strategies tumors use to avoid attacks by anti-cancer drugs.
Who Sleeps?
The Scientist and Jerome Siegel | Mar 1, 2016 | 10+ min read
Once believed to be unique to birds and mammals, sleep is found across the metazoan kingdom. Some animals, it seems, can’t live without it, though no one knows exactly why.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Inner Sanctum
Jeanne Mcadara | May 28, 2000 | 9 min read
Reagents for Nuclear Hormone Receptor Research Courtesy of Karo Bio ABEffect of an agonist (red spheres) or agonist/antagonist (green spheres) on the C terminal helix of the ligand binding domain of the estrogen receptor The survival of a living system depends on its ability to communicate with and respond to its surroundings. Even the simplest unicellular organism has surface molecules for assessing the external environment. Evolution of complex life forms required intricate methods for respo
RNA Epigenetics
Gidi Rechavi, Chuan He, and Dan Dominissini | Jan 1, 2016 | 10 min read
DNA isn’t the only decorated nucleic acid in the cell. Modifications to RNA molecules are much more common and are critical for regulating diverse biological processes.

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