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tag serine threonine kinase developmental biology microbiology

Cell Biology
The Scientist Staff | Jan 23, 1994 | 2 min read
Hot Papers Cell Biology Date: January 24, 1994, pp.16 H.Y. Lin, X.-F. Wang, E. Ng-Eaton, R.A. Weinberg, H.F. Lodish, "Expression cloning of the TGF-b type II receptor, a functional transmembrane serine/threonine kinase," Cell, 68:775-85, 1992. Herbert Y. Lin (Netherlands Institute for Developmental Biology, Utrecht): "Transforming growth factor-b1 (TGF-b1) was initially identified about a decade ago as a prototypic negative growth
Phospho-Mania
Aileen Constans | Nov 7, 2004 | 6 min read
ERK1/2 ACTIVATIONCourtesy of Biosource Internationalis plainly visible in heart tissue from an MHC-Rac1 transgenic mouse (right), compared with its normal counterpart (left). Green, pERK 1/2 (pTEpY185/187); blue, actin; red, nuclei.Protein phosphorylation is one of the most widely studied posttranslational modifications, with good reason. Many cellular signaling events rely on the addition or subtraction of phosphate groups (by kinases and phosphatases, respectively) to serine, threonine, and ty
Escaping the Heat
Deborah Fitzgerald | Nov 12, 2000 | 10+ min read
Nonradioactive Kinase Assay Kits Safety concerns and economic considerations have fueled a growing trend in the biomedical sciences: to shun the use of radioactivity when practical. Nonradioactive options for numerous applications have become widely available, including a number of nonradioactive kinase assay kits. Assays from different manufacturers employ a wide range of strategies. Most of these kits utilize antibodies, but two nonimmunochemical approaches use fluorescently tagged substrates
Phosphoprotein-Specific Antibodies
Christopher Smith | Feb 18, 2001 | 8 min read
Forty-six years ago, Edwin Krebs and colleagues changed the way researchers understood the regulation of protein activity. In a landmark paper, these authors described the regulation of glycogen phosphorylase by attachment of a phosphate group.1 Four years later, these same authors discovered that this phosphorylation event was mediated by the enzyme glycogen phosphorylase kinase (kinases are enzymes that catalyze the transfer of a phosphate group from ATP to a substrate protein).2 And nine year
Long live the worm!
Jeff Perkel | Jun 29, 2005 | 1 min read
In tomorrow's (July 1) issue of Genes & Development, Siu Sylvia Lee, of the department of molecular biology and genetics at Cornell University in Ithaca, NY, and Gary Ruvkun, of the department of genetics at Harvard Medical School, report ?the first genome-wide functional genomic screen for longevity genes.? The two teams used a library of 16,475 RNA interference constructs (created by Julie Ahringer at the University of Cambridge, UK) to inactivate genes in the nematode, Caenorhabditis eleg
The Secret Language of Cells
Chris Smith | Jan 23, 2000 | 7 min read
Cell Signaling Reagents All biological processes result from integrated and concerted molecular events. For example, enzyme catalysis is not defined solely by kinetic activity; it is the culmination of a series of events, including activation of the enzyme, substrate synthesis and availability, direct and indirect product and substrate feedback control, and interactions with inhibitors or stimulators. In essence the entire process of protein activation is a cascade of events, each serving as a
Science Research In 1992: What Fields Were The Hottest Of The Hot?
The Scientist Staff | Apr 18, 1993 | 8 min read
RANK PAPER CITATIONS 1 M. Leid, et al., "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently," Cell, 68(2): 377- 95, 24 January 1992. 58 2 J.D. Brook, et al., "Molecular basis of myotonic dystrophy; Expansion of a trinucleotide (CTG) repeat at the 3 end of a transcript encoding a protein kinase family member," Cell, 68(4):799-808, 20 February 1992. 47 3 W.O. Spitzer, et al., "The use of beta-agonists an
Integral Connections
Deborah Fitzgerald | Aug 19, 2001 | 10 min read
Click to view the PDF file: Suppliers of Integrin-Related Reagents Courtesy of Rick HorwitzReprinted with permission from the Journal of Cell BiologyPaxillin-GFP in WI38 human fibroblast cells showing paxillin turnover as cells migrate. The image is an overlay of 2 separate time points. Editor's note: A group of scientists led by M. Amin Arnaout at Massachusetts General Hospital published the first crystal structure of the human integrin aVb3 extracellular domain, on September 9, 2001.(www.sc
Battle Against Drug Addiction Must Be Waged From Better Financed Laboratories
Stanley Korenman | Jan 19, 1990 | 4 min read
The "war on drugs" will not be won in the jungles of Colombia or along the borders of the United States. Drug abuse will come under control when we, as scientists, find ways to relieve addicts of their compulsive need for a fix. Addictions are chronic diseases originating in adolescence and young adulthood. Although the decision to experiment with drugs may have been voluntary, what occurs thereafter is a physiological disorder, not a "failure of will." Susceptibility to addiction is an inhere
Gaining Headway in Brain Growth
Jim Kling | Feb 3, 2002 | 4 min read
The Faculty of 1000 is a Web-based literature awareness tool published by BioMed Central. It provides a continuously updated insider's guide to the most important peer-reviewed papers within a range of research fields, based on the recommendations of a faculty of more than 1,400 leading researchers. Each issue, The Scientist will publish a list of the 10 top-rated papers from a specific subject area, as well as a short review of one or more of the listed papers. We will also publish a selection

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