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tag serine threonine kinase developmental biology culture

Molecular Biology
The Scientist Staff | Feb 20, 1994 | 2 min read
S. Matsuda, H. Kosako, K. Takenaka, K. Moriyama, H. Sakai, T. Akiyama, Y. Gotoh, E. Nishida, "Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade," The EMBO Journal, 11:973-82, 1992. Eisuke Nishida (Department of Genetics and Molecular Biology, Institute for Virus Research, Kyoto University, Japan): "MAP kinases have been described as serine/threonine kinases that are acti
Cell Biology
The Scientist Staff | Jan 23, 1994 | 2 min read
Hot Papers Cell Biology Date: January 24, 1994, pp.16 H.Y. Lin, X.-F. Wang, E. Ng-Eaton, R.A. Weinberg, H.F. Lodish, "Expression cloning of the TGF-b type II receptor, a functional transmembrane serine/threonine kinase," Cell, 68:775-85, 1992. Herbert Y. Lin (Netherlands Institute for Developmental Biology, Utrecht): "Transforming growth factor-b1 (TGF-b1) was initially identified about a decade ago as a prototypic negative growth
An automated sampler that is collecting a sample from a sewer line.
Tracking Community Health Through Wastewater Surveillance
Charlene Lancaster, PhD | Feb 1, 2024 | 8 min read
By monitoring disease biomarkers within wastewater, researchers gain insight into disease prevalence within communities.
Phospho-Mania
Aileen Constans | Nov 7, 2004 | 6 min read
ERK1/2 ACTIVATIONCourtesy of Biosource Internationalis plainly visible in heart tissue from an MHC-Rac1 transgenic mouse (right), compared with its normal counterpart (left). Green, pERK 1/2 (pTEpY185/187); blue, actin; red, nuclei.Protein phosphorylation is one of the most widely studied posttranslational modifications, with good reason. Many cellular signaling events rely on the addition or subtraction of phosphate groups (by kinases and phosphatases, respectively) to serine, threonine, and ty
Cell Biology
The Scientist Staff | Nov 11, 1990 | 3 min read
(The Scientist, Vol:4, #22, pg. 20, November 12, 1990) (Copyright, The Scientist, Inc.) -------- S. Shenoy, J.-K. Choi, S. Bagrodia, T.D. Copeland, J.L. Maller, D. Shalloway, "Purified maturation promoting factor phosphorylates pp60c-src at the sites phosphorylated during fibroblast mitosis," Cell, 57, 763-74, 2 June 1989. Suresh Shenoy (Cornell University, Ithaca, N.Y.): "A lot of credit for this work belongs to Jung-Kap Choi (Chonnam National University, Korea), who mapped the sites of mitos
Escaping the Heat
Deborah Fitzgerald | Nov 12, 2000 | 10+ min read
Nonradioactive Kinase Assay Kits Safety concerns and economic considerations have fueled a growing trend in the biomedical sciences: to shun the use of radioactivity when practical. Nonradioactive options for numerous applications have become widely available, including a number of nonradioactive kinase assay kits. Assays from different manufacturers employ a wide range of strategies. Most of these kits utilize antibodies, but two nonimmunochemical approaches use fluorescently tagged substrates
A Phosphorylation Pioneer
Karen Hopkin | Apr 1, 2006 | 6 min read
Tony Hunter discovered tyrosine kinases because he was lazy - then the fun began
Monoclonal Antibodies Find Utility In Cell Biology
Ricki Lewis | Dec 11, 1994 | 10+ min read
But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy
Monoclonal Antibodies Find Utility In Cell Biology
Ricki Lewis | Dec 11, 1994 | 10+ min read
But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy
Biologically Active Peptides: Who Makes Them and Who Sells Them?
Paul Diehl | Sep 13, 1998 | 10+ min read
Date: September 14, 1998 Catalog Peptide Providers Table In the last 20 years or so, numerous peptides with a diverse array of biological activities have been identified. In the same time period, the advent of automated peptide synthesis has made these reagents cheap and easy to produce in large quantities. These developments have created a new class of research reagents, known as biologically active peptides. Many biologically active peptides occur naturally; however, many others have been de

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