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tag serine threonine kinase evolution

Phospho-Mania
Aileen Constans | Nov 7, 2004 | 6 min read
ERK1/2 ACTIVATIONCourtesy of Biosource Internationalis plainly visible in heart tissue from an MHC-Rac1 transgenic mouse (right), compared with its normal counterpart (left). Green, pERK 1/2 (pTEpY185/187); blue, actin; red, nuclei.Protein phosphorylation is one of the most widely studied posttranslational modifications, with good reason. Many cellular signaling events rely on the addition or subtraction of phosphate groups (by kinases and phosphatases, respectively) to serine, threonine, and ty
Escaping the Heat
Deborah Fitzgerald | Nov 12, 2000 | 10+ min read
Nonradioactive Kinase Assay Kits Safety concerns and economic considerations have fueled a growing trend in the biomedical sciences: to shun the use of radioactivity when practical. Nonradioactive options for numerous applications have become widely available, including a number of nonradioactive kinase assay kits. Assays from different manufacturers employ a wide range of strategies. Most of these kits utilize antibodies, but two nonimmunochemical approaches use fluorescently tagged substrates
Long live the worm!
Jeff Perkel | Jun 29, 2005 | 1 min read
In tomorrow's (July 1) issue of Genes & Development, Siu Sylvia Lee, of the department of molecular biology and genetics at Cornell University in Ithaca, NY, and Gary Ruvkun, of the department of genetics at Harvard Medical School, report ?the first genome-wide functional genomic screen for longevity genes.? The two teams used a library of 16,475 RNA interference constructs (created by Julie Ahringer at the University of Cambridge, UK) to inactivate genes in the nematode, Caenorhabditis eleg
Hot Papers
The Scientist Staff | Sep 27, 1992 | 4 min read
P. Langacker, M. Luo, "Implications of precision electroweak experiments for mt, r0, sin2 qw, and grand unification," Physical Review D, 44:817-22, 1991. Paul Langacker (University of Pennsylvania, Philadelphia): "This paper presents a systematic analysis of the implications of all high-precision electroweak experiments, including those at the new e+e- collider LEP at CERN in Geneva. It shows that our present `standard model' correctly describes nature down to a distance scale of 1/1000th the s
Survival Factors and Apoptosis
Tom Hollon | Apr 1, 2001 | 3 min read
For this article, Tom Hollon interviewed Anne Brunet, a postdoctoral fellow in the division of neurosciences, Children's Hospital, Harvard Medical School. Data from the Web of Science (ISI, Philadelphia) show that Hot Papers are cited 50 to 100 times more often than the average paper of the same type and age. A. Brunet, A. Bonni, M.J. Zigmond, M.Z. Lin, P. Juo, L.S. Hu, M.J. Anderson, K.C. Arden, J. Blenis, M.E. Greenberg, "Akt promotes cell survival by phosphorylating and inhibiting a forkhea
Assays Galore
Lanette Fee | Sep 21, 2003 | 9 min read
Courtesy of BD Biosciences Pharmingen  COLOR CODING: Multiplexed bead-based assays, like BD Biosciences' Cytometric Bead Array (shown), test for multiple analytes in a single vial. The key is in the colors: one hue indicates the bead ID, and the intensity of the second, how much protein has been captured. In today's fast-paced research environment, technologies for speedy, cost-efficient analyses reign supreme. As part of this general trend, techniques for multiplexing, that is, simultan
Assays by the Score
Deborah Fitzgerald | May 27, 2001 | 9 min read
Click to view the PDF file: Bead-based Fluorescent Multiplex Protein Analysis Systems Courtesy of LINCO ResearchLabMAP-based systems use internally dyed fluorescent microspheres to analyze as many as 100 different analytes concurrently. Today's competitive, high-paced research environment has stimulated the development of a host of approaches for rapid, cost-efficient analyses of large numbers of samples. In keeping with this trend, methods for simultaneously analyzing multiple species in a g
A Master Regulator in the Brain
Per Svenningsson and Paul Greengard | Oct 1, 2006 | 10+ min read
How a single protein was found to link schizophrenia and depression to drugs of abuse and addiction. 
Arabidopsis Genome
Barry Palevitz | Jan 7, 2001 | 8 min read
Courtesy National Science Foundation Headlines on the morning of December 14, 2000, trumpeted the end of a presidential election that promised to go on forever. But if California Institute of Technology molecular biologist Elliot Meyerowitz had his way, the front page would have read differently: "Plant Genome Sequenced" at the top, then, lower down, "Election Decided - See Page 2." In a tour de force that capped a year of genome blockbusters, European, Japanese, and American scientists complet

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