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Genetic analyses uncover cellular hallmarks of bladder cancer tumors that don’t respond, but interfering with one of those characteristics in a mouse model causes tumors to shrink.  

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image: New Ovarian Cancer Vaccine Shows Promise

New Ovarian Cancer Vaccine Shows Promise

By Catherine Offord | April 12, 2018

A preliminary clinical trial finds that the personalized therapy improves survival rates and has no severe side-effects.

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image: Some Antibiotics Rev Up Host Immune Response to Viruses

Some Antibiotics Rev Up Host Immune Response to Viruses

By Shawna Williams | April 9, 2018

The antimicrobial drug neomycin protects mice from some viral infections, complicating the picture of the relationship between antibiotics and susceptibility to viruses.

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image: Opinion: We Have Been Naive About Naive T Cells

Opinion: We Have Been Naive About Naive T Cells

By Theo van den Broek, José A.M. Borghans, and Femke van Wijk | April 6, 2018

Human naive T cells are far more heterogeneous than has long been appreciated, having implications for vaccine strategies.

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image: Ruth Nussenzweig, Malaria Researcher, Dies

Ruth Nussenzweig, Malaria Researcher, Dies

By Jim Daley | April 6, 2018

The microbiologist’s research led to the development of the first human malaria vaccine.

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Mice treated with an immunostimulant had better outcomes when researchers blocked the expression of TNFR2, a compound that helps tumors evade immune attack.

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In the presence of cytosolic DNA, cancer cells activate antiviral pathways that disguise them as immune cells.

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Errors in segregation during cell division can lead to inflammation in daughter cells.

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The drugs’ disruption of the microbiome makes a subsequent flavivirus infection more severe.

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A study finds that the vaccine’s effects wear off as a person ages, suggesting a need for booster shots.

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