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tag hunting genetics genomics

Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD | Jan 18, 2024 | 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
bacteria inside a biofilm
How Bacterial Communities Divvy up Duties
Holly Barker, PhD | Jun 1, 2023 | 10+ min read
Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.
Computer turns detective in the hunt for novel pathogens
Vicki Glaser(vpglaser@aol.com) | Jan 17, 2002 | 4 min read
A computational technique that finds foreign gene sequences in human tissues could identify pathogens that cause chronic diseases.
A Test Bed for Budding Technologies
Aileen Constans | Jul 4, 2004 | 6 min read
DELETION BY DESIGN:Courtesy of Guci GiaeverThe deletion cassette module used to delete each yeast gene contains two 74-basepair tags upstream and downstream (UPTAG and DNTAG) of the KanMX gene, which confers resistance to the drug geneticin. UPTAG and DNTAG contain 18 basepairs of genomic sequence to flank the yeast's open reading frame, and U1 and U2, or D1 and D2 PCR primers for amplifying a unique 20-basepair TAG region-the so-called molecular barcode. A second round of PCR adds 45 base-pairs
Will Genomics Spoil Gene Ownership?
Douglas Steinberg | Sep 3, 2000 | 8 min read
Consider a scenario for the year 2002: Using commercially available software, bioprospector "Craig Collins" spends a day scavenging the Human Genome Project (HGP) database for the alternatively spliced genes prized by Wall Street. He enters the sequences of several candidate genes into a software package that prints out the likely functions of their protein products. One protein looks like it could be pharmaceutical paydirt, so he isolates the corresponding cDNA, inserts it into a vector, then
Epigenetic Enigmas
Beth Marie Mole | Oct 16, 2012 | 3 min read
Overturning previous studies, a peculiar protozoan mysteriously uses a DNA-markup system to take out the genetic trash.   
Playing Protein Hide and Seek
Mignon Fogarty | Apr 11, 2004 | 6 min read
LIGHTING THEIR LOCATIONS:© 2002 Cold Spring Harbor PressImmunolocalization of epitope-tagged proteins. (A-E) represent cells containing HAT-tagged proteins stained with the DNA dye, DAPI, and a monoclonal antibody against hemagluttinin, α-HA. At right the images are merged. (F-J) indicates cells carrying V5 tagged proteins. The bar equals 2 μm.Aliens sifting through the remains of a lost human civilization might puzzle over the function of a ladle. But if found in a room associate
Diagnosing Cancer: A Genomics and Proteomics Approach
Tom Hollon | Sep 21, 2003 | 7 min read
In 1996, Jeff Trent and colleagues published the first paper describing DNA microarrays as tools for pinpointing gene variants underlying various tumor properties.1 Now, as president and scientific director of Translational Genomics Research Institute (TGEN), in Phoenix, Trent is using microarrays to look for gene expression patterns that can be applied to developing diagnostics. The role of microarrays, Trent says, "will be on the discovery side. Testing all 30,000 genes against a diagnosti
New Smoking Gun?
Jef Akst | Apr 1, 2010 | 4 min read
By Jef Akst New Smoking Gun? Teams come together to target the genes behind lung cancer, but the hunt is far from over. Image modified from © Alfred Pasieka / Photo Researchers, Inc. Scientists have known for years why more than 1 million people die of lung cancer every year—smoking. Thus, when it came to looking for a genetic basis to lung cancer, “there was a lot of skepticism” about the importance of such rese
Research Briefs
Maria Anderson | Oct 19, 2003 | 4 min read
Research Briefs New Genes: The Ears Have 'Em; The Worker, The Soldier, The Candlestick Maker; For Genomes Without Borders, Biobanks Unite New genes: The ears have 'em While scouring a new cDNA library, researchers in the Netherlands discovered 80 novel expressed-sequence tags, including 25 preferentially expressed in human fetal cochlea.1 The researchers from the University Medical Center in Nijmegen (UMCN) found that 155 ESTs map to loci for nonsyndromic deafness, which is not associated

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