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Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until death.

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image: Opinion: How to Define Cell Type

Opinion: How to Define Cell Type

By Sara B. Linker, Tracy A. Bedrosian, and Fred H. Gage | November 1, 2017

Advances in single-cell technologies have revealed vast differences between cells once thought to be in the same category, calling into question how we define cell type in the first place.

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image: Contributors

Contributors

By Jef Akst and Bob Grant | November 1, 2017

Meet some of the people featured in the November 2017 issue of The Scientist.

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image: Infographic: Understanding Our Diverse Brain

Infographic: Understanding Our Diverse Brain

By Sara B. Linker, Tracy A. Bedrosian, and Fred H. Gage | November 1, 2017

Recent advances in single-cell omics and other techniques are revealing variation at genomic, epigenomic, transcriptomic, and posttranscriptomic levels.

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image: To Each His Own

To Each His Own

By Mary Beth Aberlin | November 1, 2017

Every human brain is far more unique, adaptable, and vulnerable than ever suspected.

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image: Advancing Techniques Reveal the Brain’s Impressive Diversity

Advancing Techniques Reveal the Brain’s Impressive Diversity

By Sara B. Linker, Tracy A. Bedrosian, and Fred H. Gage | November 1, 2017

No two neurons are alike. What does that mean for brain function?

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image: Single-Cell RNA Sequencing Reveals Neuronal Diversity

Single-Cell RNA Sequencing Reveals Neuronal Diversity

By Catherine Offord | June 23, 2016

Using a new approach to analyze the transcriptomes of thousands of individual cell nuclei in postmortem brains, researchers identify multiple neuronal subtypes.

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image: Mosaic Mutations May Not Be Rare

Mosaic Mutations May Not Be Rare

By Anna Azvolinsky | June 5, 2015

Somatic mosaicism may be responsible for a larger proportion of genomic variability within humans than previously thought.

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image: Mosaic Mutations

Mosaic Mutations

By Kate Yandell | July 31, 2014

Some genetic abnormalities that appear to have sprung up independently in children are in fact present in a portion of their parents’ cells.

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image: Diverse Leaves May Protect Eucalyptus

Diverse Leaves May Protect Eucalyptus

By Kate Yandell | February 20, 2013

A tree in Australia was found to have genetically dissimilar leaves that varied in attractiveness to herbivores.

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