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Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
An illustration of green bacteria floating above neutral-colored intestinal villi
The Inside Guide: The Gut Microbiome’s Role in Host Evolution
Catherine Offord | Jul 1, 2021 | 10+ min read
Bacteria that live in the digestive tracts of animals may influence the adaptive trajectories of their hosts.
antibiotics antibiotics resistance persister bacteria bacteriophage
Opinion: We Need More than New Antibiotics to Fight Resistance
Neil S. Greenspan and Arturo Casadevall | Nov 1, 2019 | 3 min read
Metabolic disrupters, phages, and other approaches are going to be needed to treat the broadest possible range of patients infected by bacterial pathogens resistant to multiple drugs.
Of Cells and Limits
Anna Azvolinsky | Mar 1, 2015 | 9 min read
Leonard Hayflick has been unafraid to speak his mind, whether it is to upend a well-entrenched dogma or to challenge the federal government. At 86, he’s nowhere near retirement.
Notebook
The Scientist Staff | Mar 30, 1997 | 7 min read
The American Medical Association (AMA), not to be outdone by the recent controversies surrounding sheep cloning, wrestled with a few ethical issues of its own earlier this month in Philadelphia. At a conference entitled "Ethics and American Medicine: History, Change, and Challenge," speakers tackled subjects such as end-of-life care and the problems of managed care and health-care rationing. The meeting’s concluding session, a roundtable discussion on medicine’s future ethical chall
Biotech Faces Evolving Patent System
Douglas Steinberg | Mar 5, 2000 | 8 min read
Like medieval alchemists, modern biologists apply intricate, esoteric protocols to lowly matter, such as bacteria and rodents. Unlike alchemists, biologists successfully transmute these creatures into gold--disease-fighting pharmaceuticals and profits accruing from them. An indispensable ingredient in this dross-to-drug process is patent protection, which preserves monopoly and attracts investment. Unfortunately, the patent system isn't as ideal a catalyst as the chimerical philosopher's stone s
Notebook
The Scientist Staff | Nov 23, 1997 | 8 min read
A National Institutes of Health panel on November 5 issued a consensus statement declaring there is clear evidence that acupuncture helps alleviate nausea from chemotherapy and anesthesia. The statement indicated the need for more and better research into how acupuncture works and acknowledged that some studies show the practice helps alleviate pain, while other studies show no conclusive effects. "There is a paucity of high-quality research assessing efficacy of acupuncture compared with place
Notebook
The Scientist Staff | Apr 26, 1998 | 8 min read
WHAT FOLLOWS TAMOXIFEN? Warnings accompanied recent announcements from the University of Pittsburgh-based National Surgical Adjuvant Breast and Bowel Project and the National Cancer Institute in Bethesda, Md., that tamoxifen achieved a 45 percent reduction in the incidence of breast cancer compared to women who took a placebo in the Breast Cancer Prevention Trial. The 25-year-old drug still carries the risk of serious side effects for women over 50, officials said. But the overall results were

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