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Spark Therapeutics’s Luxturna would be the first approved therapy in the U.S. that replaces or repairs a defective gene inherited from one’s parents.

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Combined transcription and genome data from multiple tissues in hundreds of human donors reveal links between genotype and gene expression across the body.

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image: Study Raises Questions About Patient-Derived Xenografts

Study Raises Questions About Patient-Derived Xenografts

By | October 10, 2017

When transplanted into mice, tumor genomes evolve differently than they do in patients, study finds.

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Tissue recipients were treated as “guinea pigs,” says investigation leader.

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Mice receiving the treatment produced their own monoclonal antibodies and survived infection with the life-threatening pathogen Pseudomonas aeruginosa.

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image: Image of the Day: Fragile Brain

Image of the Day: Fragile Brain

By | October 3, 2017

In Fragile X syndrome—a genetic mishap that results in cognitive delays—the lack of a translation-repressing protein leads to the rampant accumulation of other proteins in the mouse brain.

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image: Giants of Circadian Biology Win Nobel Prize

Giants of Circadian Biology Win Nobel Prize

By | October 2, 2017

The award in Physiology or Medicine goes to chronobiologists Jeffrey Hall, Michael Rosbash, and Michael Young.

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image: Bathtub Bloodbath, 1793

Bathtub Bloodbath, 1793

By | October 1, 2017

French revolutionary Jean-Paul Marat took on many roles over the course of his life, including physician and scientist.

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Researchers suggest that the receptors can control early labor contractions.

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image: Contributors

Contributors

By | October 1, 2017

Meet some of the people featured in the October 2017 issue of The Scientist.

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  4. Research Links Gut Health to Neurodegeneration
    The Nutshell Research Links Gut Health to Neurodegeneration

    Rodent studies presented at the Society for Neuroscience meeting this week tie pathologies in the gastrointestinal tract or microbiome composition with Parkinson’s and Alzheimer’s diseases.

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