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Spark Therapeutics’s Luxturna would be the first approved therapy in the U.S. that replaces or repairs a defective gene inherited from one’s parents.

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Combined transcription and genome data from multiple tissues in hundreds of human donors reveal links between genotype and gene expression across the body.

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image: Study Raises Questions About Patient-Derived Xenografts

Study Raises Questions About Patient-Derived Xenografts

By | October 10, 2017

When transplanted into mice, tumor genomes evolve differently than they do in patients, study finds.

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Tissue recipients were treated as “guinea pigs,” says investigation leader.

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Mice receiving the treatment produced their own monoclonal antibodies and survived infection with the life-threatening pathogen Pseudomonas aeruginosa.

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image: Giants of Circadian Biology Win Nobel Prize

Giants of Circadian Biology Win Nobel Prize

By | October 2, 2017

The award in Physiology or Medicine goes to chronobiologists Jeffrey Hall, Michael Rosbash, and Michael Young.

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image: Bathtub Bloodbath, 1793

Bathtub Bloodbath, 1793

By | October 1, 2017

French revolutionary Jean-Paul Marat took on many roles over the course of his life, including physician and scientist.

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Researchers suggest that the receptors can control early labor contractions.

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image: Contributors

Contributors

By | October 1, 2017

Meet some of the people featured in the October 2017 issue of The Scientist.

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image: Drugging the Disorderome

Drugging the Disorderome

By | October 1, 2017

Strategies for targeting intrinsically disordered proteins

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