cancer

The immunotherapy, which targets CD22 on cancer cells rather than CD19, might prove useful in patients for whom previous T-cell treatments were unsuccessful. 

Donald Coffey, a longtime professor at Johns Hopkins University, discovered the nuclear matrix within cells and its role in DNA replication.

A team has engineered two stem cell lines into “synthetic T cells” that destroy breast cancer cells in vitro. 

The report provides evidence that goes against concerns that Monsanto’s popular herbicide, Roundup, is carcinogenic. 

New papers from a cancer journal once named as a possibly predatory publication will no longer appear in the widely used research database.

Researchers identify 72 novel genetic variants associated with breast cancer risk.

When certain melanocyte stem cells are exposed to UV rays, a molecular cascade can trigger melanoma, scientists find in mice.

The therapy, produced by Kite Pharma and owned by Gilead Sciences, is approved for use against some types of large B-cell lymphomas. 

In mice, the tumor cells are able to thwart the immune response that would kill them—but immunotherapy prevented the return of melanoma.

An analysis of contaminated literature finds that tens of thousands of papers used cell lines of questionable origins—and these were in turn cited by hundreds of thousands of other papers.

When transplanted into mice, tumor genomes evolve differently than they do in patients, study finds.

In addition to circulating in the blood as immune sentinels, macrophages play specialized roles in different organs around the body.

Scientists use stem-like cells from patients’ aggressive, triple receptor-negative breast tumors to grow cell lines for research.

Zebrafish larvae transplanted with patients’ tumors respond as their human donors do to chemotherapy.

Researchers claim that industry groups worldwide misrepresent the carcinogenicity of alcohol products.

Epinephrine’s activation of the signaling pathway Hippo is responsible for the in vitro tumor-fighting effects of serum from women who worked out.

Douglas Lowy and John Schiller, whose work led to the HPV vaccine, and Michael Hall, who discovered the TOR pathway, win this year’s prizes.

The massive sum will buy out Kite Pharma, whose cancer therapy is expected to be among the first of its type approved by the FDA.

High levels of vitamin C absorbed by blood-forming stem cells are important for their normal development. 

High-dose vitamin C injections reverse the effects of a leukemia-promoting genetic deficiency.