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tag transcriptional regulation cell molecular biology neuroscience

Diagram tracking changes in gene expression
Ticker Tape Technology Records Cell History
Danielle Gerhard, PhD | Oct 2, 2023 | 1 min read
Researchers developed a novel protein fiber that tracks transcriptional events over time in living cells. This could shine a light on gene regulation during development or after cellular perturbations.
DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
The image shows two adult prairie voles. The voles have a brown coat and are touching each other’s snouts.
Molecular Signatures of a Broken Heart
Mariella Bodemeier Loayza Careaga, PhD | Sep 8, 2023 | 3 min read
The transcriptional profiles in the brains of prairie voles changed after a long breakup, revealing a molecular shift that might help them cope with the loss of a partner.
Microfluidics: Biology’s Liquid Revolution
Laura Tran, PhD | Feb 26, 2024 | 8 min read
Microfluidic systems redefined biology by providing platforms that handle small fluid volumes, catalyzing advancements in cellular and molecular studies.
Molecular Biology
The Scientist Staff | Nov 8, 1992 | 2 min read
L.D. Kerr, J.-I. Inoue, N. Davis, E. Link, et al., "The Rel- associated pp40 protein prevents DNA binding of Rel and NF-kB: relationship with IkBb and regulation by phosphorylation," Genes & Development, 5:1464-76, 1991. Lawrence Kerr (The Salk Institute, La Jolla, Calif.): "The regulation of protooncogene Rel, a transcription factor belonging to the family of NF-kB transcription factors, is important for the well-being of the cell because its altered form, v-rel, causes lymphoid leukemias. Wh
Microscopic image of a live amoeba.
Illuminating Specimens Through Live Cell Imaging
Charlene Lancaster, PhD | Mar 14, 2024 | 8 min read
Live cell imaging is a powerful microscopy technique employed by scientists to monitor molecular processes and cellular behavior in real time.
You Are When You Eat
Iris Kulbatski, PhD | Nov 20, 2023 | 3 min read
Intermittent fasting regulates biological time and improves disrupted sleep in an Alzheimer’s disease model.
A person moving the hands of a vintage clock backwards.
Synthetic Circuits Reveal the Key to Rewinding the Cellular Clock
Charlene Lancaster, PhD | Mar 12, 2024 | 4 min read
Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells.
Molecular Biology
The Scientist Staff | Mar 15, 1992 | 2 min read
B.F. Pugh, R. Tjian, "Mechanism of transcriptional activation by Sp1: evidence for coactivators," Cell, 61:1187-97, 1990. Franklin Pugh (Howard Hughes Medical Institute, University of California, Berkeley): "The story of eukaryotic transcriptional coactivators has provoked a new way of thinking about how sequence-specific activators communicate with the basal transcriptional machinery. "The prevailing thought prior to this work was that the TFIID component of this machine was a single protein
Molecular Biology
The Scientist Staff | Sep 1, 1991 | 1 min read
S. Ghosh, D. Baltimore, "Activation in vitro of NF-kB by phosphorylation of its inhibitor IkB," Nature, 344:678-82, 1990. Sankar Ghosh (Whitehead Institute for Biomedical Research, Cambridge, Mass.): "This paper brings together two areas of rapidly moving research: the role of protein phosphorylation and control of transcriptional regulation. The inhibitor IkB not only keeps the transcription factor NF-kB in the cytoplasm--away from DNA--but also directly prevents it from binding to DNA. By sh

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