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tag hybridization cell molecular biology ecology

Green and red fluorescent proteins in a zebrafish outline the animal’s vasculature in red and lymphatic system in green in a fluorescent image. Where the two overlap along the bottom of the animal is yellow.
Serendipity, Happenstance, and Luck: The Making of a Molecular Tool
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
The common fluorescent marker GFP traveled a long road to take its popular place in molecular biology today.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
illustration of a mitochondrian inside a cell
Could Dad’s Mitochondrial DNA Benefit Hybrids?
Alejandra Manjarrez, PhD | Jan 20, 2022 | 7 min read
Studies have found that organisms can inherit mitochondria from male parents in rare instances, and both theoretical and experimental work hint that this biparental inheritance is more than just a fluke.
Tagged for Cleansing
Michele Pagano | Jun 1, 2009 | 10+ min read
Tagged for Cleansing Not just the cell's trash and recycling center, the ubiquitin system controls complex cellular pathways with elegant simplicity and precision. By Michele Pagano have always gravitated toward order. I may even take it a bit too far according to friends who liken my office to a museum. However, I like to think it not a compulsion, but a Feng Shui approach to life. With this need for order, I may have been better suited to
A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.
Defying Dogma: Decentralized Translation in Neurons
Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read
To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.
Tag, You're It
Carina Storrs | Feb 1, 2014 | 7 min read
A guide to DNA-encoded libraries for drug discovery
Weathering Hantavirus: Ecological Monitoring Provides Predictive Model
Steve Bunk | Jul 4, 1999 | 7 min read
Photo: Steve Bunk Dave Tinnin, field research associate in the University of New Mexico's biology department, takes blood samples and measurements of rodents caught on the research station grounds. At the end of a freeway exit near Soccoro, N.M., the hairpin turn onto a gravel road is marked by a sign that warns, "Wrong Way." But it isn't the wrong way if you want to reach the University of New Mexico's (UNM) long-term ecological research (LTER) station. The sign's subterfuge is the first indi
An Alternative to Two-Hybrid
Aileen Constans | Oct 28, 2001 | 2 min read
Researchers most often use techniques such as coimmunoprecipitation and yeast two-hybrid screening to study protein-protein interactions. These methods are time-consuming-the yeast two-hybrid technique can take several months to perform-and prone to false positive results. Millbury, Mass.-based Hypromatrix recently introduced AntibodyArray™ technology to combat these problems. Hypromatrix developed the AntibodyArray for the study of protein-protein interactions and protein phosphorylation,
The Yeast Two-hybrid Assay
Mark Greener(mgreener@the-scientist.com) | Aug 28, 2005 | 8 min read
No protein is an island.
Fluorophore Fingerprinting; Gene Therapy Hybrid; Low-Level Annotation
Ivan Oransky | Jul 27, 2003 | 4 min read
PATENT WATCH | Fluorophore Fingerprinting The Molecular Sciences Institute in Berkeley, Calif., has been awarded a patent for a protein fingerprint system (US patent 6,569,685, issued May 27, 2003). The patent covers a method that, in the simplest case, consists of covalently modifying reactive residues using orthogonal chemistries, by attaching one fluorophore to lysine residues under appropriate chemical conditions, and a different fluorophore to cysteine residues. "The general idea is to

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