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tag heart failure genetics genomics neuroscience

On the left is a normally developing mouse embryo, on the right is a slightly larger mouse embryo that also contains horse cells that glow green.
Chimera research opens new doors to understanding and treating disease
Hannah Thomasy, PhD, Drug Discovery News | Aug 9, 2023 | 10 min read
Animals with human cells could provide donor organs or help us understand neuropsychiatric disorders.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Collage of faces
Remembering Those We Lost in 2022
Lisa Winter | Dec 26, 2022 | 5 min read
A look at some noteworthy scientists who died this year, leaving behind a legacy of research excellence.
Notebook
Paul Smaglik | Nov 21, 1999 | 6 min read
Contents Pivotal pump Leptin limbo Clue to obesity Biotech Web site Helping hand Mapping malaria UCSD - Salk Program in Molecular Medicine HEART FAILURE RESCUE: A cross section of a mouse genetically engineered to develop heart failure (left) shows enlarged heart chambers and thin walls that are typical of the condition. A cross section from the same strain of mouse, but with the phospholamban gene (PLB) also missing, appears normal. PIVOTAL PUMP A biochemical calcium pump and the gene that con
The Genes of Parkinsonā€™s Disease
Bobby Thomas and M. Flint Beal | Feb 1, 2011 | 10 min read
The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest, bringing researchers closer to a cause—and perhaps a cure.
Epigenetics: Genome, Meet Your Environment
Leslie Pray | Jul 4, 2004 | 10+ min read
©Mehau Kulyk/Photo Researchers, IncToward the end of World War II, a German-imposed food embargo in western Holland – a densely populated area already suffering from scarce food supplies, ruined agricultural lands, and the onset of an unusually harsh winter – led to the death by starvation of some 30,000 people. Detailed birth records collected during that so-called Dutch Hunger Winter have provided scientists with useful data for analyzing the long-term health effects of prenat
Notebook
Steve Bunk | Nov 7, 1999 | 7 min read
Content Jumping DNA Semen pharming Screening for heart risk Real-time signaling PubSCIENCE starts, PubMedCentral grows When time stands still Shutting down the pump Brain gain JUMPING DNA Mutations aren't transmitted only by inheritance--they can cross species, too, according to recent findings by John F. McDonald, head of the genetics department at the University of Georgia (I.K. Jordan et al., "Evidence for the recent horizontal transfer of long terminal repeat retrotransposon," Proceedings of
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.
Decoding DNA: New Twists and Turns
Kerry Grens | Jun 1, 2013 | 10+ min read
Highlights from a series of three webinars on the future of genome research, held by The Scientist to celebrate 60 years of the DNA double helix
Frontlines
Hal Cohen | May 26, 2002 | 5 min read
Despite some success, reproductive cloning in mammals is still a tricky feat. University of Pennsylvania School of Veterinary Medicine researchers, by tracking the gene Oct4 in mice, have shown how its routine failure to reprogram after nuclear transplant commonly prevents the successful development of mammalian embryos (M. Boiani et al., "Oct4 distribution and level in mouse clones: consequences for pluripotency," Genes & Development, 6[10]:1209-19, May 15, 2002). Producing a clone requires tha

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