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tag noncoding dna microbiology disease medicine

Haydeh Payami is wearing a purple dress and an orange and pink scarf and standing in front of a whiteboard.
A Microbial Link to Parkinson’s Disease
Mariella Bodemeier Loayza Careaga, PhD | Dec 4, 2023 | 6 min read
Haydeh Payami helped uncover the genetic basis of Parkinson’s disease. Now, she hopes to find new ways to treat the disease by studying the gut microbiome.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Epithelial cells and fungal spores are marked with fluorescent dyes. Cells have an irregular shape and are shown in green and blue colors. Spores are spherical in shape and are labeled green if they are surrounded by p11 protein. A protein in mature phagosomes is labeled violet.
Fungal Spores Hijack a Host Protein to Escape Death
Mariella Bodemeier Loayza Careaga, PhD | Jun 20, 2023 | 3 min read
Uncovering the components used by Aspergillus fumigatus to avoid intracellular destruction broadens our understanding of the mold’s pathogenesis. 
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Red blood vessels that decrease in diameter as they radiate outward are pictured on a pink and white surface
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Abby Olena, PhD | Aug 18, 2021 | 3 min read
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
All Together Now
Mary Beth Aberlin | Jan 1, 2016 | 3 min read
Understanding the biological roots of cooperation might help resolve some of the biggest scientific challenges we face.
Gut Microbes for Life
Ed Yong | Jul 4, 2013 | 3 min read
Most strains of gut microbes stay with us for decades, which may prove useful for tracking our health.
Stem Cells: Safe Haven For TB
Nsikan Akpan | Feb 5, 2013 | 3 min read
Tuberculosis bacteria find shelter from drugs and the body’s defenses in bone marrow stem cells.
Picturing Infection
Kelly Rae Chi | Jan 1, 2015 | 7 min read
Whole-animal, light-based imaging of infected small mammals
Week in Review: February 27–March 3
Joshua A. Krisch | Mar 2, 2017 | 4 min read
Remembering Eugene Garfield; protecting citizens from their own genes; a suicide switch for stem cells; storing movies on DNA; sterilizing insects with Wolbachia

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