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tag transition state enzyme inhibitors culture

Better Understanding Of Cell's Life Eases Culturing
Ricki Lewis | Nov 13, 1994 | 10+ min read
"Lots of companies come out with media or reagents for this or that, and make a big splash, but they're all basically derivatives of traditional products," says Hayden Coon, a former National Institutes of Health re-searcher who is the founder of Human Cell Therapies Inc. of Chebeague Island, Maine. Advanced Biotechnologies Inc. Columbia, MD American Qualex Antibodies La Mirada, CA American Type Culture Collection (ATCC) Rockv
Better Understanding Of Cell's Life Eases Culturing
Ricki Lewis | Nov 13, 1994 | 10+ min read
"Lots of companies come out with media or reagents for this or that, and make a big splash, but they're all basically derivatives of traditional products," says Hayden Coon, a former National Institutes of Health re-searcher who is the founder of Human Cell Therapies Inc. of Chebeague Island, Maine. Advanced Biotechnologies Inc. Columbia, MD American Qualex Antibodies La Mirada, CA American Type Culture Collection (ATCC) Rockv
Contributors
The Scientist Staff | May 1, 2012 | 2 min read
Meet some of the people featured in the April 2012 issue of The Scientist.
Illustration of clear cells with orange nuclei, Toxoplasma gondii, on colorful background
Turning Toxoplasma Against Cancer
Annie Melchor | Jan 3, 2022 | 9 min read
Several research groups have found that Toxoplasma gondii infection can ramp up antitumor immune responses in mice. Can the single-cell parasite be used to develop safe treatments for humans?
hepatitis c lasker award
Six Scientists Receive Lasker Awards
Eugene Russo | Oct 15, 2000 | 7 min read
Ubiquitin-related research has made the transition from the basic to clinical arena in the past decade, and the field is now central to understanding diseases ranging from cancer to neurodegenerative disorders.
From Buckyballs to Nanotubes
Ricki Lewis | Feb 18, 2001 | 6 min read
Photos © Michael Davidson and The Florida State University These photos show the 60-carbon alkene buckminsterfullerene ("buckyballs"). This substance joins graphite and diamond as a third form of carbon molecule. Technology sometimes derives from clever combinations of tools. Merging immune system cells with cancer cells led to the hybridoma technology that produces monoclonal antibodies. A recipe of restriction enzymes, plasmids, and DNA underlies recombinant DNA and transgenic technologi
Genetics
The Scientist Staff | Dec 6, 1998 | 3 min read
H. Kiyokawa, R.D. Kineman, K.O. Manova-Todorova, V.C. Soares, E.S. Hoffman, M. Ono, D. Khanam, A.C. Hayday, L.A. Frohman, and A. Koff. "Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27Kip1," Cell, 85:721-32, 1996. (Cited in more than 155 papers since publication) Comments by Andrew Koff, associate member of the molecular biology program, Memorial Sloan-Kettering Cancer Center, New York Cyclin-dependent kinase (CDK) inhibitors act as a traffic cop of cell
A Cell-Cycle Couple Loses Its Luster
Douglas Steinberg | Dec 1, 2003 | 7 min read
Courtesy of Philipp Kaldis, © 2003 Elsevier  THE UNEXPECTED SURVIVOR: Mice that lack the CDK2 protein (-/-) survive to adulthood but are slightly smaller than their wild-type littermates (+/+). The knockouts are also sterile. After several groups reported discovering cyclin E and cyclin-dependent kinase 2 (CDK2) in 1991, a consensus emerged. It held that these protein partners are crucial in promoting the cell cycle's G1- to S-phase transition and driving cancer-cell proliferation.
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.
Scientists Use Various Methods To Tackle Protein Purification
James Kling | Jul 6, 1997 | 8 min read
Tedious, time-consuming, exasperating: Those are perhaps the three words that researchers use most commonly to describe protein purification. Proteins, and their little sisters the peptides, are among the most difficult compounds to purify. Enzyme degradation and chemical decomposition conspire to ruin protein samples throughout the steps of purification. Proteases in the original sample and varying salt concentrations can result in degradation or precipitation. Varying pH and temperature may

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