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image: A Neuroscientist’s Journey Through Madness

A Neuroscientist’s Journey Through Madness

By Barbara Lipska with Elaine McArdle | April 1, 2018

After I was diagnosed with brain cancer and started to lose my mental health, the importance of my job came into clear focus.

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Mice treated with an immunostimulant had better outcomes when researchers blocked the expression of TNFR2, a compound that helps tumors evade immune attack.

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In the presence of cytosolic DNA, cancer cells activate antiviral pathways that disguise them as immune cells.

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image: Contributors

Contributors

By The Scientist Staff | April 1, 2018

Meet some of the people featured in the April 2018 issue of The Scientist.

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Errors in segregation during cell division can lead to inflammation in daughter cells.

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image: Infographic: Structure of the Perineuronal Net

Infographic: Structure of the Perineuronal Net

By Daniela Carulli | April 1, 2018

See the web of proteins that make up these neuronal wrappings.

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The neuronal coverings that mediate synaptic changes are involved in everything from memory to psychiatric disorders, affecting autism, Alzheimer’s, and addiction.

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The drugs’ disruption of the microbiome makes a subsequent flavivirus infection more severe.

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A study finds that the vaccine’s effects wear off as a person ages, suggesting a need for booster shots.

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The findings suggest that faster synthesis, rather than decreased clearance, causes the protein to build up in neurons.

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