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A proposed definition of the disease emphasizes signs of neurodegeneration and the presence of β-amyloid and tau, rather than cognitive symptoms.

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The elimination of these glia in the mouse brain ameliorated the development of Parkinsonian neuropathologies induced by the pesticide toxin paraquat.  

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image: CRISPR Proves Promising for Treating ALS in Mice

CRISPR Proves Promising for Treating ALS in Mice

By Katarina Zimmer | December 21, 2017

The gene-editing tool was effective in disabling a defective gene responsible for some forms of amyotrophic lateral sclerosis. 

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Upping a gene’s expression in rat brains made them better learners and normalized the activity of hundreds of other genes to resemble the brains of younger animals.

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image: Prions Found in Skin of Creutzfeldt-Jakob Patients

Prions Found in Skin of Creutzfeldt-Jakob Patients

By Jef Akst | November 24, 2017

Infectious protein aggregates from the skin of human patients can cause disease in mice.

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image: Research Links Gut Health to Neurodegeneration

Research Links Gut Health to Neurodegeneration

By Jef Akst | November 13, 2017

Rodent studies presented at the Society for Neuroscience meeting this week tie pathologies in the gastrointestinal tract or microbiome composition with Parkinson’s and Alzheimer’s diseases.

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image: How Microbes May Influence Our Behavior

How Microbes May Influence Our Behavior

By Amy Lewis | September 1, 2017

Researchers are piecing together the links between the gut microbiome and mental health.

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image: Do Microbes Trigger Alzheimer’s Disease?

Do Microbes Trigger Alzheimer’s Disease?

By Jill U. Adams | September 1, 2017

The once fringe idea is gaining traction among the scientific community.

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Emerging evidence links bacterial or viral infection with the neuropathology of Alzheimer’s disease.

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Neurons derived from human induced pluripotent stem cells fill in for lost dopamine neurons in a primate model of the disease.

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