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Subscribedrug discovery
Week in Review, July 15–19
Jef Akst | Jul 19, 2013 | 5 min read
Bias in preclinical research; medical marijuana for kids; a swath of microbial genomes; plastic ocean habitats; rethinking scientific evaluation
NIH to Resurrect Old Drugs
Chris Palmer | Jun 20, 2013 | 1 min read
Academic scientists and the pharmaceutical industry will collaborate on a new program to speed up the drug development process.
DNA Unlocked - A Special 3-Part Q&A Series
The Scientist Creative Services Team in collaboration with Amgen | 1 min read
Dive deeper into the DNA Unlocked podcasts
Opinion: Bench to Bedside
Daniel Drucker | Apr 30, 2013 | 3 min read
A chance discovery made in my lab 17 years ago results in the first drug that can help patients with a rare disease.
From Toxins to Therapeutics
Dan Cossins | Mar 19, 2013 | 5 min read
Researchers are finding new drugs for chronic pain and autoimmune diseases by modifying animal venom-derived molecules that target the nervous and immune systems.
Mapping Neuronal Gene Expression to Understand Pain
The Scientist Creative Services Team in collaboration with Advanced Cell Diagnostics | 1 min read
Ted Price, Diana Tavares-Ferreira, and Stephanie Shiers discuss how mapping gene expression at the neuronal level provides insight into pain mechanisms and anti-pain drug development.
FDA Reform to Boost US Economy?
Dan Cossins | Mar 5, 2013 | 2 min read
Two experts propose replacing Phase 3 trials with smaller, faster alternatives and post-market surveillance to invigorate the pharmaceutical industry.
Teenage Drug Hunter
Dan Cossins | Mar 1, 2013 | 3 min read
An Oregon teenager spent a summer in a New York biochemistry lab helping to discover a novel molecule that could become the next commercial nonaddictive painkiller.
Manipulating the Microbiome to Manage Disease
The Scientist Creative Services Team in collaboration with Tecan | 1 min read
Cammie Lesser will discuss how she turns a probiotic into a drug-delivering machine, while Andrew Y. Koh will describe the connection between the gut microbiota and cancer immunotherapy efficacy.
Antibiotic Bouncer
Kerry Grens | Mar 1, 2013 | 2 min read
Contrary to previous assumptions that macrolide antibiotics completely block the exit tunnel of ribosomes, new evidence shows that some peptides are allowed to pass.
Is Frog Skin a Red Herring?
Ed Yong | Jan 2, 2013 | 3 min read
Despite decades of work, compounds in frog skins have failed to yield new antibiotics. Why?
A Better Hydrogel for 3D Cell Culture
The Scientist Creative Services Team in collaboration with MilliporeSigma | 2 min read
Drug screening in 3D cell cultures is possible with the right tools.
Opinion: Parachuting off the Patent Cliff
Sandra S. Lee | Dec 6, 2012 | 3 min read
As the United States edges ever closer to the dreaded fiscal cliff, the pharmaceutical industry approaches a precipice of its own.
Neil Bence: Manipulating Degradation
Kerry Grens | Dec 1, 2012 | 3 min read
Senior Scientist, Millennium Pharmaceuticals: The Takeda Oncology Company Age: 39
Technique Talk: High-Throughput Drug Screening Using 3D Cell Culture
The Scientist Creative Services Team in collaboration with MilliporeSigma | 1 min read
In this workshop, learn how to use hydrogel 3D cell culture plates for streamlined 3D cell culture colony formation, imaging, metabolic read-out, and T cell-mediated tumor cell killing.
Tumor Snipers
Megan Scudellari | Nov 1, 2012 | 7 min read
After two headline successes, companies rush to develop “smart bomb” cancer drugs.
Next Generation: The Heart Camera
Sabrina Richards | Jun 19, 2012 | 3 min read
A new camera system allows researchers to measure multiple cardiac signals at once to understand how they interact to control heart function.
Checking Checkpoints for Treating Cancer
The Scientist | 1 min read
Researchers devise strategies to improve checkpoint inhibitor therapy and predict patient response.