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tag synaptic plasticity neuroscience

SYNGAP1 helps neurons eliminate old synapses and form new ones after a novel experience (left and center left)—a process weakened in mice missing a copy of the gene (center right and right).
Autism-Linked Gene SYNGAP1 Molds Synaptic Plasticity, Learning
Angie Voyles Askham, Spectrum | Oct 26, 2021 | 4 min read
The finding may help to explain why people with SYNGAP1 mutations tend to have learning difficulties and a high tolerance for pain.
A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.
Defying Dogma: Decentralized Translation in Neurons
Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read
To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.
Panels showing different kinds of microglia
Mapping Tool Reveals Microglia’s Shape-Shifting Secrets
Angie Voyles Askham, Spectrum | Dec 14, 2022 | 4 min read
The approach could help test hypotheses about how atypical function of the brain’s immune cells contributes to autism.
The Neurobiology of Individuality
Dan Cossins | May 9, 2013 | 3 min read
Mice that explore more have higher levels of neurogenesis, suggesting a link between experience, brain plasticity, and the emergence of distinct personalities.
Scientists Strike a Cord
Rabiya Tuma | Feb 9, 2003 | 6 min read
Courtesy of SR Eng  BABY STAINS: The head of a transgenic murine embryo in which a marker enzyme has been specifically expressed in the sensory neurons of the trigeminal and dorsal root ganglia. The marker allows staining of the projections of these neurons into, among other areas, the hindbrain and spinal cord. (S.R. Eng et al., "Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice," J Neurosci, 21:541-9, 2001.) Somewhere in the 200 million bases of the human ge
Who Sleeps?
The Scientist and Jerome Siegel | Mar 1, 2016 | 10+ min read
Once believed to be unique to birds and mammals, sleep is found across the metazoan kingdom. Some animals, it seems, can’t live without it, though no one knows exactly why.
A Master Regulator in the Brain
Per Svenningsson and Paul Greengard | Oct 1, 2006 | 10+ min read
How a single protein was found to link schizophrenia and depression to drugs of abuse and addiction. 
Illuminating Behaviors
Douglas Steinberg | Jun 1, 2003 | 6 min read
Courtesy of Genevieve Anderson If not for Nobel laureates Thomas Hunt Morgan, Eric R. Kandel, and Sydney Brenner, the notion of a general behavioral model might seem odd. Behaviors, after all, are determined by an animal's evolutionary history and ecological niche. They are often idiosyncratic, shared in detail only by closely related species. But, thanks to Morgan's research in the early 20th century, and Kandel's and Brenner's work over the past 35 years, the fly Drosophila melanogaster, t
Untangling Neuronal Calcium Signaling
Amy Adams | Jan 20, 2002 | 10 min read
From the very moment of conception, calcium plays a pivotal role in fetal development. It rushes in as a wave around the egg to herald the sperm's arrival, binding to proteins that help kick off the whole developmental process. From this first influx, calcium continues to play a critical role in how the body's cells respond to outside signals. Calcium tells muscles to contract and nerves to release neurotransmitters, and is at least part of the signal that helps people form and retain memories.

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