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tag receptor cell molecular biology immunology evolution

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
3D illustration of damaged myelin sheath seen in demyelinating diseases such as multiple sclerosis.
Tracking Down Innate Immune Cells in Multiple Sclerosis
Mariella Bodemeier Loayza Careaga, PhD | Dec 4, 2023 | 5 min read
A novel PET tracer targeting a receptor in myeloid cells can help monitor disease progression in a mouse model of multiple sclerosis.
Molecular Biology
The Scientist Staff | Aug 22, 1993 | 2 min read
M. Leid, P. Kastner, R. Lyons, et al., "Purification, cloning and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently," Cell, 68:377-95, 1992. Mark Leid (Oregon State University, Corvallis): "The diverse effects of retinoic acid (RA) on development, cellular growth and differentiation, and homeostasis are mediated by two families of RA receptors that arose independently during evolution and belong to the steroid/thyroid hormone super
Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
Green and red fluorescent proteins in a zebrafish outline the animal’s vasculature in red and lymphatic system in green in a fluorescent image. Where the two overlap along the bottom of the animal is yellow.
Serendipity, Happenstance, and Luck: The Making of a Molecular Tool
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
The common fluorescent marker GFP traveled a long road to take its popular place in molecular biology today.
A bat flying in a dark cave
Turning on the Bat Signal
Hannah Thomasy, PhD | Mar 15, 2024 | 10+ min read
Scientists around the world investigate how bat immune systems cope with viral attacks and how this information could be used to keep humans safe.
A needle drawing up fluid from an unlabeled vial.
Cancer Vaccination as a Promising New Treatment Against Tumors
Shelby Bradford, PhD | Mar 15, 2024 | 10+ min read
Vaccination has beaten back infections for more than a century. Now, it may be the next big step in battling cancer.
Molecular Biology (2)
The Scientist Staff | Apr 1, 1991 | 1 min read
A. Kazlauskas, C. Ellis, T. Pawson, J.A. Cooper, "Binding of GAP to activated PDGF receptors," Science, 247:1578-81, 1990. Andrius Kazlauskas (National Jewish Center for Immunology and Respiratory Medicine, Denver): "The GTPase activator protein of ras (GAP) is one of a number of recently discovered proteins that appear to maintain nucleotide binding proteins such as ras in an inactive state, that is, coupled with GDP instead of GTP. Since regulation of GAP activity could affect cellular leve
Macrophages on the Fast Track to Tumor Defense
Laura Tran, PhD | Feb 22, 2024 | 3 min read
In a race to the tumor, a macrophage’s phenotype can give it a leg up on the competition.
Molecular Biology
The Scientist Staff | Jul 24, 1994 | 2 min read
D.H. Fremont, M. Matsumura, E.A. Stura, P.A. Peterson, I.A. Wilson, "Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb," Science, 257:919-27, 1992. Ian A. Wilson (Department of Molecular Biology, Scripps Research Institute, La Jolla, Calif.): "One of the major issues in molecular immunology is determining how a limited number of major histocompatibility complex (MHC) molecules in any individual can

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