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The Scientist

» DNA damage response

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With three recent FDA approvals, and a number of Phase 3 trials ongoing, the drugs are seeing a surge in interest.

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image: Alcohol Damages Mouse DNA

Alcohol Damages Mouse DNA

By Jef Akst | January 3, 2018

A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not repaired.

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Scientists discover transcripts from the same gene that can express both proteins and noncoding RNA.  

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image: How We Age

How We Age

By The Scientist Staff | March 1, 2015

From DNA damage to cellular miscommunication, aging is a mysterious and multifarious process.

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image: Wrangling Retrotransposons

Wrangling Retrotransposons

By Michael Van Meter, Andrei Seluanov, and Vera Gorbunova | March 1, 2015

These mobile genetic elements can wreak havoc on the genome. Researchers are now trying to understand how such activity contributes to the aging process.

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image: DNA Damage Scout

DNA Damage Scout

By Andrew P. Han | February 11, 2014

Researchers are beginning to appreciate a role for RNA polymerase beyond gene transcription.

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image: Brain Activity Breaks DNA

Brain Activity Breaks DNA

By Sabrina Richards | March 24, 2013

Researchers find that temporary double-stranded DNA breaks commonly result from normal neuron activation—but expression of an Alzheimer’s-linked protein increases the damage.

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image: DNA, Contortionist

DNA, Contortionist

By Kerry Grens | August 1, 2012

The DNA forms known as G-quadruplexes are finally discovered in human cells.

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Daniel Durocher: Change is Good

By Kerry Grens | July 1, 2012

Senior Investigator, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada. Age 40

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