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tag double strand breaks microbiology

Researchers target E. coli in the mouse gut
Modifying the Microbiome In Vivo, One Species or Gene at a Time
Niki Spahich, PhD | Feb 16, 2022 | 4 min read
To manipulate the microbiome, researchers engineered a CRISPR delivery system that precisely targets bacteria in the mouse gut.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
3D virus cells attacking a DNA strand
HIV DNA Circularizes to Bypass CRISPR-Based Treatments
Nele Haelterman, PhD | Mar 7, 2022 | 3 min read
CRISPR-mediated removal of HIV can create small, infectious DNA molecules.
Salmonella living within macrophages can survive antibiotic treatment and potentially give rise to resistance by two different mechanisms that slow or arrest their growth.
Bacteria Go Dormant to Survive Antibiotics and Restart Infections
Niki Spahich, PhD | Mar 7, 2022 | 3 min read
In Salmonella, two seemingly similar antibiotic survival strategies result from very different molecular mechanisms.
Bacteria on the skin
Biotech Tries Manipulating the Skin Microbiome
Bianca Nogrady | Apr 18, 2022 | 8 min read
Researchers are revealing the complexity of the microbial community living on the body—and paving the way for new bacteria-targeting treatments for acne and other dermatological conditions.
photograph of a woman wearing a face mask embedded with SARS-CoV-2 sensors
Researchers Create Pathogen-Sensing Face Mask
Annie Melchor | Jul 5, 2021 | 5 min read
The masks contain freeze-dried, cell-free biosensors, enabling them to detect pathogens including SARS-CoV-2.
illustration of people of different genders and races
Does Biological Sex Influence COVID-19 Outcomes?
Annie Melchor | Nov 2, 2021 | 10 min read
It’s unclear whether differing odds of dying between men and women reflect inherent differences between male and female immune systems or differences rooted in gender norms.
Broken DNA
DNA Damage Viewed with Unprecedented Clarity
Amanda Heidt | Aug 15, 2022 | 3 min read
A new tool called PRISM draws on virus-host interactions and a DNA repair pathway to help researchers visualize how cellular stress may contribute to neurodegenerative disease.
Keeping CRISPR in Check
Anna Azvolinsky | Dec 14, 2016 | 3 min read
In bacteriophage genomes, researchers find three anti-CRISPR proteins that naturally inhibit CRISPR-Cas9 in one bacterial species and can do the same in human cells. 
multicolor DNA sequencing gel
Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments
Ryan Layer, The Conversation | May 27, 2022 | 5 min read
Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.

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