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tag double strand breaks genetics genomics culture
Infographic: How Prime Editing Works
Ida Emilie Steinmark, PhD
| Sep 8, 2023
| 4 min read
Prime editing is one of the most promising forms of genome editing because it uses only single-stranded DNA breaks.
Infographic: How Stray DNA Can Land in Double-Strand Breaks
Katarina Zimmer
| Mar 1, 2019
| 1 min read
A study on yeast illuminates how insertions may occur.
A CRISPR Alternative for Correcting Mutations That Sensitize Cells to DNA Damage
Deanna MacNeil, PhD
| Oct 10, 2022
| 3 min read
Researchers turned to base editors to correct mutations causing the rare genetic disease Fanconi anemia without inducing double-strand DNA breaks.
All Roads Lead to Genome Editing
Danielle Gerhard, PhD
| Feb 9, 2024
| 6 min read
Shondra Pruett-Miller has taken many paths in her career with her love of genome editing always as a guiding light.
Twisted DNA Increases CRISPR Off-target Effects
Shelby Bradford, PhD
| Feb 8, 2024
| 4 min read
Understanding how Cas9 binds off-target sequences can help researchers refine CRISPR-mediated genome editing.
Stem Cell Editing Repairs Severe Immunodeficiency
Kamal Nahas, PhD
| Mar 20, 2024
| 5 min read
Scientists hoping to treat immunodeficiencies using gene therapy have found a way to edit stem cells in mice without disrupting gene regulation.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD
| Mar 15, 2024
| 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
DNA Truth or Dare
Sam Kean
| Jul 1, 2012
| 3 min read
Learning the intricacies of your own genetic profile is a double-edged sword.
Turning on the Bat Signal
Hannah Thomasy, PhD
| Mar 15, 2024
| 10+ min read
Scientists around the world investigate how bat immune systems cope with viral attacks and how this information could be used to keep humans safe.
Genotoxic Effects of Base and Prime Editing
Kamal Nahas, PhD
| Jan 12, 2024
| 5 min read
A risk-benefit analysis of gene editing tools in stem cells revealed that base and prime editing carry vulnerabilities similar to those of CRISPR-Cas9, but at a reduced rate.
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