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tag structural biology cell molecular biology disease medicine

Molecular/Structural Biology
The Scientist Staff | Jan 22, 1995 | 2 min read
J.H. Brown, T.S. Jardetzky, J.C. Gorga, L.J. Stern, R.G. Urban, J.L. Strominger, D.C. Wiley, "Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1," Nature, 364:33-9, 1993. (Cited in 235 publications through December 1994) Comments by Jerry H. Brown This paper is the first description of the three-dimensional structure of a class II human leukocyte antigen (HLA). Also known as histocompatibility antigens, the HLA molecules are present on various cell surfaces t
Infusion of Artificial Intelligence in Biology
Meenakshi Prabhune, PhD | Feb 23, 2024 | 10 min read
With deep learning methods revolutionizing life sciences, researchers bet on de novo proteins and cell mapping models to deliver customized precision medicines.
Microfluidics: Biology’s Liquid Revolution
Laura Tran, PhD | Feb 26, 2024 | 8 min read
Microfluidic systems redefined biology by providing platforms that handle small fluid volumes, catalyzing advancements in cellular and molecular studies.
Glowing red DNA on bluish background
Redesigning Medicine Using Synthetic Biology
Alison Halliday, PhD, Technology Networks | Jun 21, 2023 | 5 min read
Drawing inspiration from nature, synthetic biology offers exciting opportunities to transform the future of medicine.
Molecular Biology
The Scientist Staff | Jan 6, 1991 | 1 min read
B. Berkhout, R.H. Silverman, K.-T. Jeang, "Tat trans-activates the human immunodeficiency virus through a nascent RNA target," Cell, 59, 273-82, 20 October 1989. Ben Berkhout (National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Md.): "The unique feature of this study was the use of RNA-refolding mutagenesis. Rearrangement of RNA structures was first described by Charles Yanofsky [Stanford University] to explain the process of transcriptional attenuation ["Transcription atten
Molecular Biology
The Scientist Staff | Feb 17, 1991 | 3 min read
R.J. Bandziulis, M.S. Swanson, G. Dreyfuss, "RNA-binding proteins as developmental regulators," Genes and Development, 3, 431-7, April 1989. Gideon Dreyfuss (University of Pennsylvania School of Medicine, Philadelphia): "Protein structural comparisons led to the discovery of identifying and unifying features shared by RNA-binding proteins of the nucleus and cytoplasm. Many of these ribonucleoproteins contain an RNA-binding domain (RBD) of approximately 90 amino acids. This amino acid sequence
Molecular Biology
Osamu Chisaka | Aug 16, 1992 | 1 min read
Osamu Chisaka (University of Utah School of Medicine, Salt Lake City): “This paper is the first report about mice with an inactivated Hox gene— mammalian homologues of fruit fly homeotic genes that define segmented structures of the body through the anterior-posterior axis. This paper has been 'hot' partly because there are 40 or so closely related Hox genes in the mammalian genome, and many researchers have been investigating their functions. In addition, this paper not only describ
Molecular Biology
The Scientist Staff | Nov 11, 1990 | 2 min read
(The Scientist, Vol:4, #22, pg. 20, November 12, 1990) (Copyright, The Scientist, Inc.) -------- M.P. Scott, J.W. Tamkun, G.W. Hartzell III, "The structure and function of the homeodomain," Biochimica et Biophysica Acta, 989, 25-48, 28 July 1989. Matthew P. Scott (Stanford University School of Medicine, Calif.): "The review is really a celebration of an exciting time in the study of the DNA-binding protein fragment called a homeodomain. People in dozens of labs are contributing to the fun, fin
Molecular Biology
The Scientist Staff | Jan 20, 1991 | 3 min read
C.K. Glass, S.M. Lipkin, O.V. Devary, M.G. Rosenfeld, "Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer," Cell, 59, 697-708, 17 November 1989. Christopher K. Glass (School of Medicine, University of California, San Diego, La Jolla): "Retinoic acid receptors appear to exert profound effects on vertebrate development by binding to target genes and altering the rates at which they are transcribed in response to retinoic acid. Because t
Structural Biology
The Scientist Staff | Mar 2, 1997 | 2 min read
Edited by: Karen Young Kreeger J.P. Griffith, J.L. Kim, E.E. Kim, M.D. Sintchak, J.A. Thomson, M.J. Fitzgibbon, M.A. Fleming, P.R. Caron, K. Hsiao, M.A. Navia, "X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex," Cell, 82:507-22, 1995. (Cited in close to 70 publications as of February 1997) Comments by James P. Griffith and Joseph L. Kim, Vertex Pharmaceuticals Inc., Cambridge, Mass. FK506 is an immunosuppressant drug used for preventing graft

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