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image: How Gaining and Losing Weight Affects the Body

How Gaining and Losing Weight Affects the Body

By | January 17, 2018

Millions of measurements from 23 people who consumed extra calories every day for a month reveal changes in proteins, metabolites, and gut microbiota that accompany shifts in body mass.

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image: Primary Cilia in Neurons Linked to Obesity

Primary Cilia in Neurons Linked to Obesity

By | January 8, 2018

Three studies—one of mice and two of human genetics—describe the role of two proteins, adenylyl cyclase and melanocortin 4 receptor, in the development of obesity and diabetes. 

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image: Hormone Loss Prevents Obesity and Diabetes in Mice

Hormone Loss Prevents Obesity and Diabetes in Mice

By | November 6, 2017

Asprosin—involved in a rare disease called neonatal progeroid syndrome—targets neurons to stimulate appetite, and blocking the hormone wards off weight gain in rodents.

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image: Olfaction Determines Weight in Mice

Olfaction Determines Weight in Mice

By | July 5, 2017

Animals lacking a sense of smell stayed thinner than their smelling counterparts, despite eating the same amount.

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Children born to obese parents are at increased risk of failing motor development and cognitive tests, according to an NIH-led study.

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Obesity-associated microbiome composition can persist after weight loss, affecting the exchange of metabolites between a mouse and its resident bugs, researchers report.

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Post-publication peer review prompts the authors to clarify the ages of mice used in their experiments and share additional data.

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image: Bile Benefits

Bile Benefits

By | November 1, 2015

Diverting the bile duct around a long stretch of the small intestine could treat obesity without cutting out chunks of the digestive tract.

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image: Gut Microbiome After Weight-Loss Surgery

Gut Microbiome After Weight-Loss Surgery

By | August 5, 2015

Gastric bypass surgery can have long-term effects on the composition of the gut microbiome, a small study shows.

4 Comments

image: Pioneering Obesity Researcher Dies

Pioneering Obesity Researcher Dies

By | July 31, 2015

Jules Hirsch, who described the link between body weight and metabolism, has died at age 88.

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