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tag molecular biology evolution cell molecular biology

Molecular Biology
The Scientist Staff | Aug 22, 1993 | 2 min read
M. Leid, P. Kastner, R. Lyons, et al., "Purification, cloning and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently," Cell, 68:377-95, 1992. Mark Leid (Oregon State University, Corvallis): "The diverse effects of retinoic acid (RA) on development, cellular growth and differentiation, and homeostasis are mediated by two families of RA receptors that arose independently during evolution and belong to the steroid/thyroid hormone super
Molecular Biology
The Scientist Staff | Jan 6, 1991 | 1 min read
L. Osborn, C. Hession, R. Tizard, C. Vassallo, et al., "Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes," Cell, 59, 1203-11, 22 December 1989. Laurelee Osborn (Biogen Inc., Cambridge, Mass.): "Vascular cell adhesion molecule 1 (VCAM1) is of interest to scientists in several disciplines, particularly those studying cell-cell adhesion mechanism and the mechanisms by which the inflammatory response begins and progre
Molecular Cell Biology
Neeraja Sankaran | Sep 17, 1995 | 2 min read
A. Noda, Y. Ning, S.F. Venable, O.M. Pereira-Smith, J.R. Smith, "Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen," Experimental Cell Research, 211:90-8, 1994. (Cited in nearly 150 publications through August 1995) Comments by James R. Smith, Baylor College of Medicine The major finding described in this paper, says James R. Smith, a professor in the division of molecular virology at Baylor College of Medicine and codirector of the Roy M. and Phyllis Gou
Molecular Biology
The Scientist Staff | Feb 16, 1992 | 1 min read
D.E. Williams, J. Eisenman, A. Baird, C. Rauch, et al., "Identification of a ligand for the c-kit proto-oncogene," Cell, 63:167-74, 1990. N.G. Copeland, D.J. Gilbert, B.C. Cho, P.J. Donovan, et al., "Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles," Cell, 63:175-83, 1990. D.M. Anderson, S.D. Lyman, A. Baird, J.M. Wignall, et al., "Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane
Molecular Biology
The Scientist Staff | Feb 20, 1994 | 2 min read
M. Pagano, G. Draetta, P. Jansen-Durr, "Association of cdk2 kinase with the transcription factor E2F during S phase," Science, 255:1144-7, 1992. M. Pagano, R. Pepperkok, F. Verde, W. Ansorge, G. Draetta, "Cyclin A is required at two points in the human cell cycle," EMBO Journal, 11:961-71, 1992. Giulio F. Draetta (Mitotix Inc., Cambridge, Mass.): "The ordered progression of a eukaryotic cell through the cell cycle is absolutely r
Molecular Biology
The Scientist Staff | May 12, 1991 | 2 min read
R.G. Goodwin, D. Friend, S.F. Ziegler, R. Jerzy, et al., "Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily," Cell, 60:941-51, 1990. Raymond Goodwin (Immunex Corp., Seattle): "Interleukin-7 (IL-7) was cloned based on its ability to induce the proliferation of pre-B cells, and has subsequently been shown to have effects on immature and mature T cells. The cloning of the receptor for IL-7 allows for studies to iden
Molecular Biology
The Scientist Staff | Mar 15, 1992 | 1 min read
T.J. Schall, M. Lewis, K.J. Koller, A. Lee, G.C. Rice, G.H.W. Wong, T. Gatanoga, et al., "Molecular cloning and expression of a receptor for human tumor necrosis factor," Cell, 61:361-70, 1990. Thomas Schall (Genentech Inc., South San Francisco, Calif.): "The biological effects of the protein known as tumor necrosis factor (TNF) have puzzled inves- tigators for years. Though binding studies have revealed that virtually all mammalian cells possess TNF receptors, the molecule's biological activit
Molecular Biology
The Scientist Staff | Dec 6, 1992 | 2 min read
R. Glynne, S. H. Powis, S. Beck, A. Kelly, L-A. Kerr, J. Trowsdale, "A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC," Nature, 353:357-360, 1991. Richard Glynne (Imperial Cancer Research Fund, London, England): "The mechanism by which the body's immune system recognizes and kills virally infected cells but passes over healthy cells has intrigued immunologists for many years. An important breakthrough came when Alain Townsend at the John R
Molecular Biology
The Scientist Staff | Mar 1, 1992 | 2 min read
D.W. Nebert, D.R. Nelson, M.J. Coon, R.W. Estabrook, et al., "The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature," DNA and Cell Biology, 10:1-14, 1991. Daniel W. Nebert (University of Cincinnati Medical Center): "This review is the third in a series of comprehensive, up- to-date compilations of data about members of the large cytochrome P450 gene superfamily. It serves to organize a large--and growing--body of sequencing and mapping data on 154 P450 genes
MOLECULAR BIOLOGY
Paris | Jul 19, 1992 | 1 min read
Michel Philippe (Universite de Rennes, Rennes Cédex, France): "In yeast, two critical points of the cell cycle (Start and G1/S) are regulated by the same protein. This protein, called p34cdc2, is coded by the genes cdc2 in Schizzosaccharomyces pombe and CDC28 in Saccharomyces cerevisiae. By complementation of yeast mutants, proteins from higher eucaryotes homologous to cdc2 have been cloned. Moreover, p34cdc2 has been shown to be one of the main components of the well-known M-phase promotin

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