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Cancer's Other Conduit
The Scientist Staff | Sep 7, 2003 | 7 min read
Courtesy of Elsevier  DEADLY SPREAD: A: an insulinoma (Ins) in a Rip1Tag2 transgenic mouse. LYVE-1 immunohistochemistry demonstrates the presence of lymphatic vessels in connective tissue, but not near islets of Langerhans. B: Rip1Tag2 mice were crossed with mice which overexpress VEGF-C in pancreatic b-cells. C: An insulinoma cell breaks through a lymphatic vessel. D: An intralymphatic tumor cell mass forms. E: In a lymph node, lymphocytes (L) are surrounded by tumor cells (T). F: Immunof
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Macrophages Play a Double Role in Cancer
Amanda B. Keener | Apr 1, 2018 | 10+ min read
Macrophages play numerous roles within tumors, leaving cancer researchers with a choice: eliminate the cells or recruit them.
Top 10 Innovations 2015
The Scientist | Dec 1, 2015 | 10+ min read
The newest life-science products making waves in labs and clinics
Capturing Cancer Cells on the Move
Nicholette Zeliadt | Apr 1, 2014 | 9 min read
Three approaches for isolating and characterizing rare tumor cells circulating in the bloodstream
Integrin Signaling at a Crossroads
Megan Stephan(mstephan@the-scientist.com) | Sep 11, 2005 | 6 min read
Integrins serve as the cell's conduit to the outside world, sensing the external environment and passing on instructions: differentiate or not, adhere or move on, live or die.
The Rise of Free, Global Gene Expression Data Sets
Jim Kling | Apr 1, 2002 | 5 min read
See related Techlink, "The Data Analysis Grand Prix". For this article, Jim Kling interviewed Patrick O. Brown, Howard Hughes Medical Institute investigator and professor in the department of biochemistry, Stanford University Medical School in Stanford, Calif., and John N. Weinstein, senior investigator at the National Cancer Institute and head of the genomics and bioinformatics group, in Bethesda, Md. Data from the Web of Science show that Hot Papers are cited 50 to 100 times more often than t
DNA Chips Enlist in War on Cancer
Douglas Steinberg | Feb 20, 2000 | 10+ min read
Graphic: Cathleen Heard The boy had the classic symptoms of acute leukemia--low blood counts and tumor cells circulating in his bloodstream. But the diagnosis was tentative because the tumor cells looked atypical for leukemia. So doctors extracted RNA from the cells, made cDNAs from the RNA, and incubated the cDNAs with a chip bearing thousands of single-stranded gene fragments on its glass surface. The hybridization pattern suggested, surprisingly, that the boy had a muscle tumor. After confirm
Interferons And Interleukins: From Bench To Bedside
Ricki Lewis | Mar 21, 1993 | 7 min read
Interferons (IFs) and interleukins (ILs) are immune system biochemicals at the intersection of basic research and medical technology. Part of the class of secreted cellular regulators known as cytokines, IFs and ILs have experienced dizzying public relations ups and downs, hailed one season as tomorrow's wonder drugs, derided the next as toxic side effects emerge during therapy. type_Document_Title_here With many questions about the basic biology of these enigmatic immunochemicals stil

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