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tag gas chromatography mass spectrometry cell molecular biology microbiology

Mass Spectrometry Applications for Proteomics
Jeffrey Perkel | Aug 19, 2001 | 10+ min read
Click to view the PDF file: Proteomic Mass Spectrometry Equipment Courtesy of CiphergenCiphergen's SELDI process, a MALDI variant that includes a surface-based enrichment step Early in the twentieth century, scientists puzzled over the observation that certain elements that were otherwise physically indistinguishable from each other nevertheless exhibited different radioactive decay characteristics. These elements would ultimately come to be known as isotopes, but at the time this concept was
An Introduction to Metabolomics
An Introduction to Metabolomics
Rebecca Roberts, PhD | Oct 17, 2023 | 5 min read
As the closest reflection of biological phenotype, metabolomics provides critical information about human health and disease.
Special Report: New Tools Join Old In Microbiological Research
Ricki Lewis | Apr 28, 1991 | 7 min read
Microbiological Research Author: RICKI LEWIS AND HOLLY AHERN, p.24 Microbiology has evolved from ancient art to savvy science. Yesterday's painstaking tasks of culturing and identifying microorganisms have been joined by rapid detection strategies and intricate genetic manipulations. Microbiologists may still streak specimens on agar plates and wait overnight for bacterial colonies to grow, as was done two centuries ago, but today they may also use spectrophotometers or chromatographs. Gas
What Kind of Mass Spec User are You?
Jeffrey M. Perkel | Feb 1, 2007 | 5 min read
Whether studying proteins, nucleic acids, or small molecules, there's an ideal configuration for everyone.
Designing a More Accurate Protein Census
Douglas Steinberg | Apr 1, 2001 | 4 min read
Graphic: Leza BerardoneApplied Biosystems will soon begin testing new mass spectrometry machines designed to identify proteins in as many as 1,000 samples per hour. For the machines to work as planned, however, each sample must be prefractionated down to just a handful of proteins, according to Stephen A. Martin, director of the company's proteomics research center in Framingham, Mass. This example suggests how the slower protocols leading to mass spec are as important to the progress of proteom
Cracking the Complex
Jeffrey M. Perkel | Nov 1, 2015 | 8 min read
Using mass spec to study protein-protein interactions
New Technology Spurs on Proteomics
Jennifer Fisher Wilson | Apr 1, 2001 | 7 min read
Graphic: Leza BerardoneOne recent morning at the Applied Biosystems proteomics research center in Framingham, Mass., scientist Jason Marchese patiently used a pipettor to place tiny samples onto a 2-inch-by-2-inch plate. He was surrounded by technology as simple as 2-D gel electrophoresis apparatus and as cutting-edge as a high-throughput system that uses automated robotics for multidimensional liquid chromatography separation of proteins and an automated workstation that uses the latest in mass
Capillary Electrophoresis Gains Acceptance As Applications Increase
Howard Goldner | May 1, 1995 | 10 min read
Through the years, a variety of separation techniques have been used by researchers in their continuing challenge to accurately separate and identify analytes of interest from complex mixtures. Numerous procedures, physical as well as chemical, conducted in an assortment of vessels, are often used to achieve this goal. During the past 25 years, column techniques such as gas chromatography (GC) and high-performance liquid chromatography (HPLC) have led to successful separation and identification
Bacteria Harbor Geometric “Organelles”
Amber Dance | Dec 1, 2018 | 10+ min read
Microbes, traditionally thought to lack organelles, get a metabolic boost from geometric compartments that act as cauldrons for chemical reactions. Bioengineers are eager to harness the compartments for their own purposes.
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.

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