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tag nuclear pore cell molecular biology

Nuclear Pores Come into Sharper Focus
André Hoelz and Daniel H. Lin | Dec 1, 2016 | 10 min read
Solving a long-standing structural puzzle will open the door to understanding one of the cell’s most enigmatic machines.
A close up of several modular puzzle pieces.
Making Connections: Click Chemistry and Bioorthogonal Chemistry
Deanna MacNeil, PhD | Feb 13, 2024 | 5 min read
Simple, quick, and modular reactions allow researchers to create useful molecular structures from a wide range of substrates.
A Peek at the Pore
Bennett Daviss(bdaviss@the-scientist.com) | Apr 24, 2005 | 6 min read
As the gateway to the nucleus, the nuclear pore complex manages hundreds of intricate cargo-handling operations every second.
The Bytes Behind Biology
Andrea Gawrylewski | Aug 1, 2007 | 5 min read
The Bytes Behind Biology BigBen's 21 cabinets hold 4,136 processors Performing 21 trillion calculations per second, a supercomputer in Pittsburgh provided the first atomic-level look at the inner workings of the nuclear pore complex. That's just one of its accomplishments. By Andrea Gawrylewski ARTICLE EXTRAS 1 Preexisting models, based on electron microscopy and experimental work, had suggested four calcium binding sites to facilitate neurotransmission. Stiles
Architectural role for BCL6
Jonathan Weitzman(jonathanweitzman@hotmail.com) | Nov 6, 2000 | 1 min read
Nuclear BTB/POZ proteins are often concentrated into discrete nuclear subdomains, but the role of these nuclear compartments is unclear. The BCL6 proto-oncogene, frequently altered in non-Hodgkin lymphoma, encodes a POZ/zinc finger protein that shows a characteristic localization in nuclear aggregates. In the November Molecular and Cellular Biology Albagli et al. used a tetracycline-regulated, epitope-tagged BCL6 allele to explore the significance of BCL6 aggregates (Mol Cell Biol 2000, 20:8560-
Biological Informatics: The Virtual Cell: Modeling Cellular Processes
Nadia Halim | May 9, 1999 | 4 min read
Biochemist John Carson uses The Virtual Cell to compare experimental and simulation results. Biologists are generating a vast amount of data on the molecular events that occur in the cell. Since a computer might the best tool for researchers to integrate all the information and sort out the complexities of a typical biological process, the next logical step would be to develop appropriate software for the job. A team at the University of Connecticut (UConn) Health Center in Farmington is attemp
a false color transmission electron microscope image of a neuronal cell body, with lysosomes colored dark green
Scientists Uncover Major Pathway Cells Use to Mend Leaky Lysosomes
Holly Barker, PhD | Oct 6, 2022 | 3 min read
Damaged lysosomes are repaired by a lipid-based signaling pathway dubbed PITT that could be targeted to treat neurodegenerative disease, its discoverers say.
Tag! Purifying Proteins with Affinity Chromatography
Aileen Constans(aconstans@the-scientist.com) | Feb 27, 2005 | 6 min read
What is now a standard protein laboratory technique began as an act of desperation.
Changing somatic cell function
Tudor Toma(t.toma@ic.ac.uk) | May 13, 2002 | 1 min read
Functional reprogramming of somatic cells can be achieved using a nuclear and cytoplasmic extract derived from another somatic cell type.
Monoclonal Antibodies Find Utility In Cell Biology
Ricki Lewis | Dec 11, 1994 | 10+ min read
But, just as antibodies are finding increasing utility in cell biology, a new Food and Drug Administration classification for those products with clinical utility may affect researchers' access to the important technology (see accompanying story). Monoclonal History MAbs were born in 1975, when Georges Kohler and Cesar Milstein at the Medical Research Council Laboratories in Cambridge, England, fused two types of cells to form a hy

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