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tag adeno associated virus microbiology developmental biology neuroscience

Reprogrammed Müller Glia Restore Vision in Mice
Ashley Yeager | Aug 15, 2018 | 4 min read
A double gene-transfer therapy transformed the non-neuronal cells into rod photoreceptors in the retinas of animal models of congenital blindness.
Those We Lost in 2019
Ashley Yeager | Dec 30, 2019 | 6 min read
The scientific community said goodbye to Sydney Brenner, Paul Greengard, Patricia Bath, and a number of other leading researchers this year.
Top 10 Innovations 2021
2021 Top 10 Innovations
The Scientist | Dec 1, 2021 | 10+ min read
The COVID-19 pandemic is still with us. Biomedical innovation has rallied to address that pressing concern while continuing to tackle broader research challenges.
Top Ten Innovations 2011
The Scientist | Jan 1, 2012 | 10+ min read
Our list of the best and brightest products that 2011 had to offer the life scientist
2020 Top 10 Innovations
The Scientist | Dec 1, 2020 | 10+ min read
From a rapid molecular test for COVID-19 to tools that can characterize the antibodies produced in the plasma of patients recovering from the disease, this year’s winners reflect the research community’s shared focus in a challenging year.
Creative Expression: Mammalian Expression Vectors and Systems
Christopher Smith | Feb 1, 1998 | 7 min read
Date: February 2, 1998 Chart 1 Chart 2 Prokaryotic expression systems, reviewed in the September 1, 1997, issue of The Scientist were part of the early repertoire of research tools in molecular biology. Although the expression of recombinant protein in prokaryotes provided a means to develop other research tools (antibodies, for example ) and study basic aspects of biological function, the scope and depth of this research were limited, especially with regard to eukaryotic proteins. The de novo
Happenings
The Scientist Staff | Jan 10, 1988 | 10 min read
PEOPLE AWARDS DEATHS OPPORTUNITIES ETCETERA MEETINGS NEW PUBLICATIONS Clayton F. Caills, director-at-large of the American Chemical Society board, has been elected ACS president for 1989. Callis retired from his position as director of environmental operations for Monsanto Fibers & Intermediates Co. in 1985, and became vice president of Chelan Associates, an environmental consulting firm in St. Louis. Ernest L. Ellel, ACS board chairman and WR. Kenan Professor of Chemistry at the Univers
Letters
Ronald Paque | Oct 4, 1987 | 6 min read
As a disenfranchised victim of the peer-review system, I consider that the myriad proposals for modifying peer review are less than encouraging. In his letter “Can Peer Review Be Improved?” (May 4, 1987, P. 10), Moshe Wolman is more than correct when he points out the inhibitory effect peer review has on science. Innovative, creative ideas that depart from dogma are usually given unfundable priorities, especially when dealing with NIH. In 1985 NIH received more than 30,000 proposa
Articles Alert
Simon Silver | Jun 24, 1990 | 7 min read
The Scientist has asked a group of experts to comment periodically upon recent articles that they have found noteworthy. Their selections, presented herein every issue, are neither endorsements of content nor the result of systematic searching. Rather, the list represents personal choices of articles the columnists believe the scientific community as a whole may also find interesting. Reprints of any articles cited here may be ordered through The Genuine Article, 3501 Market St., Philadelphia,
Building a Better Biosensor
Mike May | May 23, 2004 | 8 min read
A GRADIENT OF PORE SIZES:Courtesy of Michael J. Sailorimparts a rainbow of colors to a porous silicon chip, one of a variety of new biosensor technologies in development around the world. The different colors correspond to different sized pores, ranging from a few nanometers to hundreds of nanometers in diameter. These pores help the device discriminate and detect proteins and other molecules based on their size.One morning in March 1995, the deadly nerve gas sarin wafted through the Tokyo subwa

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