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tag adeno associated virus genetics genomics neuroscience

Regulating adeno-associated virus
Jonathan Weitzman(jonathanweitzman@hotmail.com) | Dec 10, 2001 | 1 min read
Adeno-associated virus is an attractive vector for gene therapy as it is non-pathogenic and integrates into a specific site in the human genome. In the December 11 Early Edition of the Proceedings of the National Academy of Sciences, Toni Cathomen and colleagues, at The Salk Institute for Biological Studies in California describe a genetic screen for cellular proteins that can bind to a viral DNA sequence important for replication and integration (Proc Natl Acad Sci USA, 2001 10.1073/pnas.261567
DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
Learn about establishing a Gene Therapy Manufacturing Strategy 
Considerations for Gene Therapy Manufacturing Strategies
Thermo Fisher Scientific | Oct 24, 2022 | 1 min read
Discover tips for setting up and optimizing adeno-associated virus production.
Illustration showing mouse being injected with AAV mixture
Infographic: Taking AAV screening to the next level
Mariella Bodemeier Loayza Careaga, PhD | Mar 8, 2024 | 2 min read
DNA barcodes in AAV vectors technology simplified AAV screening.
Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Professor Alexandra Whiteley and graduate student Autumn Matthews look at an image of a western blot on their laboratory computer.
An Ancient Viral Protein May Play a Key Role in ALS
Aditi Subramaniam, PhD | Aug 15, 2023 | 4 min read
Researchers find that UBQLN2 gene dysfunction causes a virus-like protein to accumulate in cells, which changes gene expression and may contribute to disease progression in amyotrophic lateral sclerosis (ALS).
Bio-Rad Launches Vericheck ddPCR Replication Competent Lentivirus and Replication Competent AAV Kits for Cell and Gene Therapy Production
Bio-Rad Laboratories | Feb 27, 2024 | 2 min read
Rapid, Sensitive, and Validated Detection of Viral Replication Genes Using Droplet Digital™ PCR During Cell and Gene Therapy Production
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Dog Study Revives Concerns About Virus Used for Gene Therapy
Jef Akst | Jan 6, 2020 | 2 min read
Canines treated with an adeno-associated viral (AAV) vector showed evidence that the therapeutic DNA held within the virus can integrate into the host genome, risking the activation of oncogenes.

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