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tag ip developmental biology

Stem Cell Trial for Eye Disease Commences
Jef Akst | Sep 12, 2014 | 2 min read
Researchers at the RIKEN Center for Developmental Biology will treat the first patient in its clinical trial testing an induced pluripotent stem cell-based treatment for age-related macular degeneration.
A Living Legacy
Megan Scudellari | Jan 13, 2010 | 10 min read
A Living Legacy At the birthplace of stem cell research, the next generation of scientists continues to advance the field. By Megan Scudellari In Toronto’s downtown Discovery District, world-class stem cell researchers populate the buildings like athletes at the Olympics. On University Avenue, Andras Nagy, a renowned innovator in induced pluripotent stem (iPS) cells, works at the Samuel Lunenfeld Research Institute, housed within the towering Mount Sin
Untangling Neuronal Calcium Signaling
Amy Adams | Jan 20, 2002 | 10 min read
From the very moment of conception, calcium plays a pivotal role in fetal development. It rushes in as a wave around the egg to herald the sperm's arrival, binding to proteins that help kick off the whole developmental process. From this first influx, calcium continues to play a critical role in how the body's cells respond to outside signals. Calcium tells muscles to contract and nerves to release neurotransmitters, and is at least part of the signal that helps people form and retain memories.
High-Throughput Epigenetics Analyses
Jyoti Madhusoodanan | Jan 1, 2018 | 7 min read
Emerging technologies help researchers draw mechanistic links between metabolism and epigenetic modification of DNA.
New Method for Reprogramming Cells
Kerry Grens | Jan 29, 2014 | 3 min read
An external stressor, such as low pH or a mechanical squeeze, can send differentiated mouse cells back to a pluripotent state.
Lab Tools: Close Encounters
Jeffrey M. Perkel | Oct 1, 2008 | 7 min read
Protein-protein interaction assays for all occasions.
The Shape of Heredity
Susan M. Gasser | Jul 1, 2009 | 10+ min read
By Susan M. Gasser The Shape of Heredity Tracking the dance of DNA and structural proteins within the nucleus shows that placement makes the difference between gene activity and silence. What's true of the best architecture is also true of cellular structures: form follows function. We biologists often take this mantra to an extreme, searching for the function of a molecule or gene without much consideration of its structure, its phys
Scientists Strike a Cord
Rabiya Tuma | Feb 9, 2003 | 6 min read
Courtesy of SR Eng  BABY STAINS: The head of a transgenic murine embryo in which a marker enzyme has been specifically expressed in the sensory neurons of the trigeminal and dorsal root ganglia. The marker allows staining of the projections of these neurons into, among other areas, the hindbrain and spinal cord. (S.R. Eng et al., "Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice," J Neurosci, 21:541-9, 2001.) Somewhere in the 200 million bases of the human ge

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