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tag chromosome folding domains neuroscience genetics genomics microbiology

streaks of white bacterial colonies on a blue Petri dish
Many Bacteria and Archaea Promoters Work Forward and Backward
Jack J. Lee | May 28, 2021 | 4 min read
New analyses find that divergent transcription, in which one promoter directs the expression of two adjacent genes oriented in opposite directions, is conserved across all domains of life.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Artist&rsquo;s rendition of red SARS-CoV-2 coronaviruses floating near blue strands of DNA.
COVID-19 Infections May Reshape Genetic Landscape
Holly Barker, PhD | Mar 30, 2023 | 3 min read
SARS-CoV-2 infection triggers structural changes in the host cell’s DNA, which provide a molecular explanation for long COVID, a new study suggests. 
bacteria inside a biofilm
How Bacterial Communities Divvy up Duties
Holly Barker, PhD | Jun 1, 2023 | 10+ min read
Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics.
Genetic Parasites and a Whole Lot More
Barry Palevitz | Oct 15, 2000 | 10+ min read
Photo: Ori Fragman, Hebrew University Hordeum spontaneum, the plant studied for BARE-1 retroelements. With genome sequences arriving almost as regularly as the morning paper, the public's attention is focused on genes--new genes to protect crops against pests; rogue genes that make bacteria resistant to antibiotics; faulty genes that, if fixed, could cure diseases such as muscular dystrophy. What many people don't realize is that genes account for only part of an organism's DNA, and in many c
The Genes of Parkinsonā€™s Disease
Bobby Thomas and M. Flint Beal | Feb 1, 2011 | 10 min read
The minority of Parkinson’s cases now known to have genetic origins are shedding light on the cellular mechanisms of all the rest, bringing researchers closer to a cause—and perhaps a cure.
A Genomic View of Oceanic Life
Leslie Pray | Oct 14, 2001 | 6 min read
Last year, scientists discovered a unique, energy-generating, light-absorbing protein previously unknown to exist in oceanic life. They named the protein proteorhodopsin.1 The bacteria that harbor it are a distinct phylogenetic group known as SAR86. This year, scientists learned that as much as 10 percent of the ocean's surface is occupied by these proteorhodopsin-containing bacteria--as many as 1x105 cells per milliliter of sea water.2 The researchers, led by marine microbiologist Edward DeLo
Imaging Chromatin to Deduce Function from Form
Marissa Fessenden | Dec 1, 2018 | 7 min read
Researchers describe their tools for probing how the physical shape of the genome affects genes’ function.
Notable
Jeffrey Perkel | Jan 20, 2002 | 3 min read
T. Sicheritz-Pontén, S.G. Andersson, "A phylogenomic approach to microbial evolution," Nucleic Acids Research, 29[2]:545-52, Jan. 15, 2001. F1000 Rating: Must Read "The paper describes methods and computer programs for automated phylogenetic analysis of complete genome datasets, as well as useful visualization tools for the results. The tools should be useful to those looking for genes that may have unusual evolutionary histories relative to other genes in the same genome." —Jonath
Crohn's: An Autoimmune or Bacterial-Related Disease?
Maria Anderson | Aug 19, 2001 | 8 min read
In 1996 geneticist Gilles Thomas and colleagues at the INSERM, the French Institute for Health and Medical Research in Paris, reported that IBD1, a region on the long arm of chromosome 16, was a Crohn's disease susceptibility locus.1 Five years later, in a second study, they announced that they had pinpointed the exact gene. The researchers contended that the connection between Crohn's and NOD2, the implicated gene located in IBD1, provided evidence to support the hypothesis that the disease is

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