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tag c difficile evolution disease medicine

bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
Wrestling with Recurrent Infections
Gayatri Vedantam and Glenn S. Tillotson | May 1, 2011 | 10+ min read
Clostridium difficile is evolving more robust toxicity, repeatedly attacking its victims, and driving the search for alternative therapies to fight the infection.
Matthieu Groussin sits with three other people on stools in front of a low table, on which there are several bowls of food. Another person stands above Groussin spooning something into a bowl.
Q&A: Gathering Diverse Microbiome Samples
Katherine Irving | Nov 3, 2022 | 8 min read
Cofounders of a microbiome biobank speak with The Scientist about their new partnership with nonprofit OpenBiome and how to ethically work with donors.
Week in Review: June 16–20
Tracy Vence | Jun 20, 2014 | 2 min read
Early Neanderthal evolution; developing antivirals to combat polio; the mouth and skin microbiomes; insect-inspired, flight-stabilizing sensors
multicolor DNA sequencing gel
Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments
Ryan Layer, The Conversation | May 27, 2022 | 5 min read
Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.
Bacteria on the skin
Biotech Tries Manipulating the Skin Microbiome
Bianca Nogrady | Apr 18, 2022 | 8 min read
Researchers are revealing the complexity of the microbial community living on the body—and paving the way for new bacteria-targeting treatments for acne and other dermatological conditions.
Who Sleeps?
The Scientist and Jerome Siegel | Mar 1, 2016 | 10+ min read
Once believed to be unique to birds and mammals, sleep is found across the metazoan kingdom. Some animals, it seems, can’t live without it, though no one knows exactly why.
Wrestling with Recurrent Infections
Gayatri Vedantam and Glenn S. Tillotson | May 1, 2011 | 9 min read
By Gayatri Vedantam and Glenn S. Tillotson Wrestling with Recurrent Infections Clostridium difficile is evolving more robust toxicity, repeatedly attacking its victims, and driving the search for alternative therapies to fight the infection. photoillustration by Sean Mccabe; Science Photo Library (boy); Sebastian Kaulitzki/ Istockphoto.com (Intestines); Olena Timashova/Istockphoto.com (Green bacteria); Jiri Flogel/Istockphoto.com (Blue bacteria) As infectiou
2018 Top 10 Innovations
The Scientist | Dec 1, 2018 | 10+ min read
Biology happens on many levels, from ecosystems to electron transport chains. These tools may help spur discoveries at all of life's scales.

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