David Secko | Jun 20, 2004 | 6 min read
TRANSCRIPTIONAL DIVERSITY:Horst Feldmann, Ludwig-Maximilians-Universität MüchenTranscription by Pol II is dependent on a number of multi-subunit complexes including TFIID, a general transcription factor complex, and SAGA. Both deliver the TATA-box binding protein (TBP) to promoters and they share a number of TBP associated factors (TAFs). While they have overlapping contributions to gene expression, TFIID function appears to dominate gene regulation at 90% of the measurable genome, mos