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image: Immunotherapy Promising for Diabetes: Study

Immunotherapy Promising for Diabetes: Study

By Aggie Mika | August 9, 2017

A small clinical trial demonstrates that peptide immunotherapy can halt the progression of early-stage type 1 diabetes.

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image: Stem Cells Seek Out Tumors Based on Stiffness

Stem Cells Seek Out Tumors Based on Stiffness

By Shawna Williams | July 26, 2017

The technique, demonstrated in mice using engineered mesenchymal stem cells, has potential for both diagnosis and treatment.

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image: FDA Votes Yes on CAR T-Cell Therapy

FDA Votes Yes on CAR T-Cell Therapy

By Aggie Mika | July 13, 2017

A Food and Drug Administration advisory panel unanimously calls for agency approval of the cell therapy for the treatment of resistant leukemia. 

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In two early trials, vaccines tailored to the mutations in individuals’ cancers appeared to protect 12 of 19 patients against relapse. 

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image: CAR T-Cell Trials Boast Promising Results

CAR T-Cell Trials Boast Promising Results

By Diana Kwon | June 6, 2017

The results of two small clinical trials show that the immunotherapy is effective for multiple myeloma patients, at least in the near term.

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image: Rare T Cells Fight Cancer

Rare T Cells Fight Cancer

By Jef Akst | May 1, 2017

A new approach to immunotherapy finds that the immune-cell clonotypes that come to the rescue start out at very low frequencies.

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image: Contributors

Contributors

By Diana Kwon | April 1, 2017

Meet some of the people featured in the April 2017 issue of The Scientist.

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image: Gel Scaffolds for Delivery of Immunotherapies

Gel Scaffolds for Delivery of Immunotherapies

By Rachel Berkowitz | April 1, 2017

Using biocompatible polymers to carry cancer immune therapies directly to the tumor

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image: Making CAR T-Cell Therapy Safer

Making CAR T-Cell Therapy Safer

By Catherine Offord | April 1, 2017

Following a spate of patient deaths in clinical trials testing modified T cells for the treatment of cancer, researchers work to reduce the treatment’s toxicity without sacrificing efficacy.

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Measuring PD-L1 levels was a great start. Now we need to quantify more protein biomarkers, assess the tumor mutational landscape, and examine immune cell signatures, too.

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