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Genetic Mutations Can Be Benign or Cancerous—a New Method to Differentiate Between Them Could Lead to Better Treatments
Ryan Layer, The Conversation | May 27, 2022 | 5 min read
Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.
The Scientist’s 2019 Gift Guide
Emily Makowski | Dec 13, 2019 | 2 min read
Wishing you a sciency season’s greetings!
Aptamers Identify Protein Signatures
Ricki Lewis | Apr 1, 2001 | 3 min read
Graphic: Leza BerardoneA technique not deemed "sexy" enough for commercialization a decade ago may finally find its niche in proteomics. SomaLogic Inc. of Boulder, Colo. is pioneering aptamers, which are modified DNA molecules that bind specific proteins in body fluid samples. Aptamers are initially selected for specific binding activities from a huge starting pool, then variants are obtained during subsequent rounds of amplification. The technology builds on the ability of aptamers to bind tena
A Small Revolution
Erica Westly | Oct 1, 2011 | 5 min read
In fewer than 15 years, nanomedicine has gone from fantasy to reality.
Life Sentences: Ontology Recapitulates Philology
Sydney Brenner | Mar 17, 2002 | 3 min read
A few years ago, at a meeting at Dana Point in Southern California, I mistook the number of the room in which our breakfast was to be served and found myself in a room full of strangers. 
NAS Honors Sagan And 14 Other Science Achievers
Neeraja Sankaran | Apr 17, 1994 | 8 min read
Three of the 13 awards this year are going to astronomers, including the academy's highest honor--the Public Welfare Medal--which is being given to Carl E. Sagan, 59, David Duncan Professor of Astronomy and Space Sciences at Cornell University, Ithaca, N.Y. Every year, NAS presents this medal (the only award without an accompanying cash prize) to an individual who has made extraordinary use of science for the public good. Perhaps
NAS Honors Sagan And 14 Other Science Achievers
Neeraja Sankaran | Apr 17, 1994 | 8 min read
Three of the 13 awards this year are going to astronomers, including the academy's highest honor--the Public Welfare Medal--which is being given to Carl E. Sagan, 59, David Duncan Professor of Astronomy and Space Sciences at Cornell University, Ithaca, N.Y. Every year, NAS presents this medal (the only award without an accompanying cash prize) to an individual who has made extraordinary use of science for the public good. Perhaps
Assays Galore
Lanette Fee | Sep 21, 2003 | 9 min read
Courtesy of BD Biosciences Pharmingen  COLOR CODING: Multiplexed bead-based assays, like BD Biosciences' Cytometric Bead Array (shown), test for multiple analytes in a single vial. The key is in the colors: one hue indicates the bead ID, and the intensity of the second, how much protein has been captured. In today's fast-paced research environment, technologies for speedy, cost-efficient analyses reign supreme. As part of this general trend, techniques for multiplexing, that is, simultan
Ribozymes: Hearkening Back to an RNA World
Jeffrey Perkel | Sep 15, 2002 | 9 min read
Illustration: Ned Shaw LIKE MOLECULAR TOY-MAKERS, ribozyme researchers create tools with evolutionary, diagnostic, and therapeutic applications. Nearly 20 years ago, Tom Cech and Sidney Altman discovered that some naturally occurring RNAs could perform enzymatic reactions, earning these researchers the 1989 Nobel Prize in chemistry. Scientists have now identified several examples of RNA enzymes, or ribozymes. Most make or break the phosphodiester bonds in nucleic acid backbones, but some
Articles Alert
Simon Silver | Jul 8, 1990 | 7 min read
The Scientist has asked a group of experts to comment periodically upon recent articles that they have found noteworthy. Their selections, presented herein every issue, are neither endorsements of content nor the result of systematic searching. Rather, the list represents personal choices of articles the columnists believe the scientific community as a whole may also find interesting. Reprints of any articles cited here may be ordered through The Genuine Article, 3501 Market St., Philadelphia,

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