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tag roger tsien neuroscience

Arsenic and Old Protein Labels
Brendan Maher | May 26, 2002 | 2 min read
For a team at the University of California, San Diego, nine years of tinkering with arsenic paid off in the development of a new technique that can tag proteins with different colors over time and even zero in to electron microscopic resolution. Roger Tsien, Howard Hughes Medical Institute investigator and professor of pharmacology, chemistry, and biochemistry at UCSD, says the project started with the suggestion from a colleague that one can tag a two-cysteine sequence in a protein with a singl
Micro Master
Jef Akst | Jan 1, 2015 | 4 min read
Thomas Deerinck has been at the helm of a microscope for more than four decades. And he’s got lots to show for it, including a half a dozen placements in the Nikon Small World competition.
The Tiniest of Life's Rafts
Jill Adams | Oct 10, 2004 | 6 min read
LIPID RAFTS INSIDE AND OUT:© 2002 AAASIn the outer leaflet (A), sphingolipids and cholesterol form less fluid microdomains (B) called lipid rafts, which are enriched for GPI-proteins. Microdomains may contain more rigid subdomains (C) enriched for the sphingolipid ganglioside GM1. The membrane inner leaflet contains microdomains (D) with unknown lipid composition enriched for prenylated proteins. In contrast, caveolin and proteins carrying the two saturated fatty acyl chains become concentr
Untangling Neuronal Calcium Signaling
Amy Adams | Jan 20, 2002 | 10 min read
From the very moment of conception, calcium plays a pivotal role in fetal development. It rushes in as a wave around the egg to herald the sperm's arrival, binding to proteins that help kick off the whole developmental process. From this first influx, calcium continues to play a critical role in how the body's cells respond to outside signals. Calcium tells muscles to contract and nerves to release neurotransmitters, and is at least part of the signal that helps people form and retain memories.

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