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tag dna double stranded breaks cell molecular biology

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
3D representation of a DNA helix and with a base offset from the main helix, illustrating the concept of base editing.
A CRISPR Alternative for Correcting Mutations That Sensitize Cells to DNA Damage
Deanna MacNeil, PhD | Oct 10, 2022 | 3 min read
Researchers turned to base editors to correct mutations causing the rare genetic disease Fanconi anemia without inducing double-strand DNA breaks.
Does DNA Damage Cause Cancer?
Charles Q. Choi | Jun 1, 2007 | 4 min read
Back-to-back studies pose double-strand breaks as initiating tumorigenesis.
DNA Damage Linked to Brain Overgrowth in Autism
Abby Olena, PhD | Feb 5, 2020 | 4 min read
Cell lines from individuals with macrocephalic autism spectrum disorder have an increased number of double-strand breaks in the DNA of long neural genes.
The prime editing machinery comprises a prime editing guide RNA (pegRNA) and a Cas9 nickase enzyme fused to a reverse transcriptase.
Infographic: How Prime Editing Works
Ida Emilie Steinmark, PhD | Sep 8, 2023 | 4 min read
Prime editing is one of the most promising forms of genome editing because it uses only single-stranded DNA breaks.
Twisted DNA Increases CRISPR Off-target Effects
Shelby Bradford, PhD | Feb 8, 2024 | 4 min read
Understanding how Cas9 binds off-target sequences can help researchers refine CRISPR-mediated genome editing.
Green and red fluorescent proteins in a zebrafish outline the animal’s vasculature in red and lymphatic system in green in a fluorescent image. Where the two overlap along the bottom of the animal is yellow.
Serendipity, Happenstance, and Luck: The Making of a Molecular Tool
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
The common fluorescent marker GFP traveled a long road to take its popular place in molecular biology today.
Fifty Years with Double-Stranded RNA
Alexander Rich | Dec 1, 2006 | 10 min read
Fifty Years with Double-Stranded RNA Courtesy of Alexander Rich The scientist who discovered hybridization and the "other" double helix describes what it meant to biology. By Alexander Rich ARTICLE EXTRAS An interactive look at original documents with commentary: The discovery of the dsRNA helix, 1956 Predictions on the regulatory potential of dsRNA, 1961 RNA Timeline: A History in Hybridization and StructurePodcast: Alex Rich discusses th
Conceptual image of DNA strands
Downsizing DNA
Aparna Nathan, PhD | Dec 4, 2023 | 10 min read
Some species remove up to 90 percent of their genomes during development, but why or how this happens is still a mystery.
Individual bacterial transcriptomes each plotted as a single point create a ring-shaped structure.
Rapidly Dividing Bacteria Coordinate Gene Expression and Replication
Kamal Nahas, PhD | Mar 15, 2024 | 4 min read
E. coli divides faster than it can replicate its genome, while simultaneously expressing its genes. Scientists recently revealed the intricate molecular coordination that makes this possible.

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