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tag rna polymerase disease medicine

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
Haydeh Payami is wearing a purple dress and an orange and pink scarf and standing in front of a whiteboard.
A Microbial Link to Parkinson’s Disease
Mariella Bodemeier Loayza Careaga, PhD | Dec 4, 2023 | 6 min read
Haydeh Payami helped uncover the genetic basis of Parkinson’s disease. Now, she hopes to find new ways to treat the disease by studying the gut microbiome.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Microfluidics: Biology’s Liquid Revolution
Laura Tran, PhD | Feb 26, 2024 | 8 min read
Microfluidic systems redefined biology by providing platforms that handle small fluid volumes, catalyzing advancements in cellular and molecular studies.
T regulatory cell in red sandwiching an antigen presenting cell in blue
Gut Bacteria Help T Cells Heal Muscle: Study
Natalia Mesa, PhD | Mar 14, 2023 | 4 min read
Regulatory T cells in the colon travel to muscles to promote wound healing in mice, raising questions about how antibiotics may impact injury recovery.
Image of the tissue surrounding a pancreatic tumor thickening and scarring.
How Pancreas Injuries Can Cause Cancer in Mice
Dan Robitzski | Nov 9, 2021 | 4 min read
A key mutation turns healing cells into cancer promoters.
DNA Damage Scout
Andrew P. Han | Feb 11, 2014 | 4 min read
Researchers are beginning to appreciate a role for RNA polymerase beyond gene transcription.
Research Notes
Ricki Lewis | May 14, 2000 | 4 min read
Introducing RNA Polymerase The long-sought crystal structure of RNA polymerase II, aka PolII, reveals a complex and tenacious machine. As the linchpin in gene expression, that machine "is arguably the most important protein in biology," says Roger Kornberg, professor of structural biology at Stanford University School of Medicine, who led the two-decade-long effort (P. Cramer et al., "Architecture of RNA polymerase II and implications for the transcription mechanism," Science, 288:640-9, April
A rendering of a human brain in blue on a dark background with blue and white lines surrounding the brain to represent the construction of new connections in the brain.
Defying Dogma: Decentralized Translation in Neurons
Danielle Gerhard, PhD | Sep 8, 2023 | 10+ min read
To understand how memories are formed and maintained, neuroscientists travel far beyond the cell body in search of answers.
a pair of scissors cuts a film strip that's curled into a helix
Alternative Splicing Provides a Broad Menu of Proteins for Cells
Gabrielle M. Gentile, Hannah J. Wiedner, Emma R. Hinkle, and Jimena Giudice | Jan 13, 2020 | 10+ min read
It’s now clear that gene transcripts can be constructed in various ways, yet many questions remain about the process.

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