Alzheimer's Disease, neuroscience

Mutations within the MS4A gene cluster have been linked to changes in protein levels that affect disease risk.

Using super-resolution microscopy, scientists learned how mutant tau causes a memory-related protein to clump up in mouse neurons.

He developed an MRI-based map of the human cortex, discovered genetic risk factors for neurodegenerative diseases, and wrote about his struggles with ALS.

Exposing mice to an hour of 40-hertz stimuli every day for a week reduced levels of amyloid-β plaques and tau protein, and improved cognition.

The protein expression data, which are freely available online, could help identify new drug targets for the disease.

The observation could pave the way for a blood test to predict disease progression in people with a genetic predisposition to developing the neurodegenerative disorder.

Studies have demonstrated that magnetic and electrical currents can enhance memory in human subjects, but the technology is not yet ready for prime time.

One variant limited the brain’s ability to use glucose.

Boosting both neurogenesis and a brain-derived growth factor can mimic the cognitive benefits of exercise in a mouse mode of Alzheimer’s disease.

In a clinical trial, patients on the highest injected dose had 30 percent less cognitive decline over time than people on a placebo.

In a longitudinal study, researchers find that elderly people with higher pressure were more likely to show signs of Alzheimer’s disease in brain tissue.

The test uses levels of plasma amyloid-β to estimate the buildup of protein plaques in the brain.

The company’s recent effort to find new treatments for Alzheimer’s ended in disappointment.

Rodent studies presented at the Society for Neuroscience meeting this week tie pathologies in the gastrointestinal tract or microbiome composition with Parkinson’s and Alzheimer’s diseases.

The University of Rhode Island neurotoxicologist and dean came to the U.S. for college in the 1980s. 

Researchers describe how gene expression in different human brain regions is altered with age.

Dale Schenk, who worked to develop a vaccine for Alzheimer’s disease, has passed away at age 59.

Environmental magnetite in the human brain; prion structure takes shape; watching E. coli evolve in real time; learning from others’ behavior