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tag animal testing immunology neuroscience

Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
Panels showing different kinds of microglia
Mapping Tool Reveals Microglia’s Shape-Shifting Secrets
Angie Voyles Askham, Spectrum | Dec 14, 2022 | 4 min read
The approach could help test hypotheses about how atypical function of the brain’s immune cells contributes to autism.
Histology showing IL-6 expression
Immune Molecule Alters Cellular Makeup of Human Brain Organoids
Charles Q. Choi, Spectrum | Apr 17, 2023 | 4 min read
The changes may help explain the link between maternal infection and autism, though more research is needed.
neuron surrounded by immune cells
Meningitis Bacteria Trigger Headaches, Then Sneak Into the Brain
Natalia Mesa, PhD | Mar 6, 2023 | 3 min read
Researchers find that bacteria stimulate a headache-causing pain pathway to suppress the immune system and infect the brain. 
Microglia stained black
Opinion: Harnessing Microglia Cells to Stave Off Neurodegeneration
Kristine Zengeler, The Conversation | Dec 8, 2022 | 5 min read
Dialing up the activity of a protein called SYK in the brain’s “janitors” could provide an avenue to treat Alzheimer’s and other neurodegenerative diseases.
Rendering of a light blue NLRP3 inflammasome against a black background
Inflammation in Brain’s Immune Cells Triggers Depressive Behavior in Mice
Dan Robitzski | Nov 17, 2022 | 5 min read
In stressful conditions, specialized protein complexes in microglia induce neurotoxic activity in astrocytes that leads to the change in behavior.
3D image of a neuron cell network with a red glow representing inflammation.
New Insight into Brain Inflammation Inspires New Hope for Epilepsy Treatment 
Deanna MacNeil, PhD | Jun 1, 2023 | 2 min read
Clinicians and researchers teamed up to investigate how inappropriate proinflammatory mechanisms contribute to the pathogenesis of drug-refractory epilepsy.
Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em >E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
Rashmi Shivni, Drug Discovery News | May 20, 2023 | 10 min read
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
early-life stress, histone, chromatin, epigenetics, epigenetic modification, methylation, DNA, protein, stress, adversity, mice, genetics, genomics
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021 | 5 min read
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
A close-up of a fruit fly head with antenna clearly visible in front of its red eyes
Bacterial Infections Disrupt Flies’ Sense of Smell
Abby Olena, PhD | Jul 21, 2021 | 4 min read
The temporary loss of olfaction stops the flies from eating any more of whatever it is that made them sick.

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