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image: Getting Your Sugar Fix

Getting Your Sugar Fix

By Kate Yandell | April 1, 2015

A guide to glycan microarrays

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image: In Custody

In Custody

By Wudan Yan | April 1, 2015

Expert tips for isolating and culturing cancer stem cells

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image: Professional Marksman

Professional Marksman

By Anna Azvolinsky | April 1, 2015

Charles Sawyers, who began his research career just as the genetic details of human oncogenes were emerging, codeveloped Gleevec, the quintessential targeted cancer therapy.

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image: Setbacks and Great Leaps

Setbacks and Great Leaps

By Sue Armstrong | April 1, 2015

The tale of p53, a widely studied tumor suppressor gene, illustrates the inventiveness of researchers who turn mishaps into discoveries.

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image: Signaling Resistance

Signaling Resistance

By Jenny Rood | April 1, 2015

Activating signaling pathways, rather than individual genes, reveals roles for both growth and dedifferentiation in establishing resistance to cancer treatments.

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image: The CAR T-Cell Race

The CAR T-Cell Race

By Vicki Brower | April 1, 2015

Tumor-targeting T-cell therapies are generating remarkable remissions in hard-to-beat cancers—and attracting millions of dollars of investment along the way.

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image: The Challenges of Precision

The Challenges of Precision

By Adam Marcus | April 1, 2015

Researchers face roadblocks to treating an individual patient’s cancer as a unique disease.

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image: To Each His Own

To Each His Own

By Mary Beth Aberlin | April 1, 2015

Cancer treatment becomes more and more personal.

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image: Toggling Between Life and Death

Toggling Between Life and Death

By Ashley P. Taylor | April 1, 2015

In estrogen receptor–positive breast cancer, the transcription factor IRF1 tips the balance between cellular suicide and survival through autophagy.

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image: Yvonne Saenger: Immunotherapy Pioneer

Yvonne Saenger: Immunotherapy Pioneer

By Jef Akst | April 1, 2015

Assistant Professor, Department of Medicine, Columbia University. Age: 41

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