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tag autophagy disease medicine ecology

Eat Yourself to Live: Autophagy’s Role in Health and Disease
Vikramjit Lahiri and Daniel J. Klionsky | Mar 1, 2018 | 10+ min read
New details of the molecular process by which our cells consume themselves point to therapeutic potential.
bacteria and DNA molecules on a purple background.
Engineering the Microbiome: CRISPR Leads the Way
Mariella Bodemeier Loayza Careaga, PhD | Mar 15, 2024 | 10+ min read
Scientists have genetically modified isolated microbes for decades. Now, using CRISPR, they intend to target entire microbiomes.
Weathering Hantavirus: Ecological Monitoring Provides Predictive Model
Steve Bunk | Jul 4, 1999 | 7 min read
Photo: Steve Bunk Dave Tinnin, field research associate in the University of New Mexico's biology department, takes blood samples and measurements of rodents caught on the research station grounds. At the end of a freeway exit near Soccoro, N.M., the hairpin turn onto a gravel road is marked by a sign that warns, "Wrong Way." But it isn't the wrong way if you want to reach the University of New Mexico's (UNM) long-term ecological research (LTER) station. The sign's subterfuge is the first indi
Breakthrough Prizes for Life Scientists
Tracy Vence | Dec 4, 2016 | 2 min read
Awards of $3 million each go to five researchers in the life sciences, recognizing their pioneering work on autophagy, DNA-damage response, Wnt signaling, and more.
A fruit bat in the hands of a researcher
How an Early Warning Radar Could Prevent Future Pandemics
Amos Zeeberg, Undark | Feb 27, 2023 | 8 min read
Metagenomic sequencing can help detect unknown pathogens, but its widespread use faces challenges.
Longevity
Jill Adams(juadams@the-scientist.com) | May 8, 2005 | 7 min read
During autophagy-literally "self-eating"-cells deliver cytoplasmic constituents, including whole organelles, to the lysosome for degradation.
The Proteasome: A Powerful Target for Manipulating Protein Levels
John Hines and Craig M. Crews | May 1, 2017 | 10+ min read
The proteasome’s ability to target and degrade specific proteins is proving useful to researchers studying protein function or developing treatments for diseases.
Week in Review: December 5–9
Tracy Vence | Dec 11, 2016 | 6 min read
Anonymity prevails in PubPeer litigation; USPTO hears CRISPR IP arguments; critical incident reporting for preclinical research; brain waves and Alzheimer’s disease; Breakthrough Prizes
An illustration of green bacteria floating above neutral-colored intestinal villi
The Inside Guide: The Gut Microbiome’s Role in Host Evolution
Catherine Offord | Jul 1, 2021 | 10+ min read
Bacteria that live in the digestive tracts of animals may influence the adaptive trajectories of their hosts.
African Sleeping Sickness: A Recurring Epidemic
Ricki Lewis | May 12, 2002 | 5 min read
African trypanosomiasis is making an unwelcome comeback. But unlike other returning diseases, this one has a drug treatment—eflornithine—that disappeared from the market when it failed to cure cancer. Yet like Viagra's origin from a curious side effect in a clinical trial, so too was eflornithine reborn. "When it was discovered that it removes mustaches in women, it suddenly had a market: western women with mustaches," says Morten Rostrup, president of the international council for M

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