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tag gene therapy ecology cell molecular biology immunology

DNA molecule.
Finding DNA Tags in AAV Stacks
Mariella Bodemeier Loayza Careaga, PhD | Mar 7, 2024 | 8 min read
Ten years ago, scientists put DNA barcodes in AAV vectors, creating an approach that simplified, expedited, and streamlined AAV screening. 
Different colored cartoon viruses entering holes in a cartoon of a human brain.
A Journey Into the Brain
Danielle Gerhard, PhD | Mar 22, 2024 | 10+ min read
With the help of directed evolution, scientists inch closer to developing viral vectors that can cross the human blood-brain barrier to deliver gene therapy.
Bugs as Drugs to Boost Cancer Therapy
Danielle Gerhard, PhD | Jan 18, 2024 | 7 min read
Bioengineered bacteria sneak past solid tumor defenses to guide CAR T cells’ attacks.
Green and red fluorescent proteins in a zebrafish outline the animal’s vasculature in red and lymphatic system in green in a fluorescent image. Where the two overlap along the bottom of the animal is yellow.
Serendipity, Happenstance, and Luck: The Making of a Molecular Tool
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
The common fluorescent marker GFP traveled a long road to take its popular place in molecular biology today.
Microscopic Bowls Uncover the Secrets of Protein Secretions
Rebecca Roberts, PhD | Jan 30, 2024 | 4 min read
Researchers developed a “test tube” so tiny that it can hold a single cell. These vials enabled them to connect protein secretion levels with surface markers and transcriptome data from the same cell. 
A needle drawing up fluid from an unlabeled vial.
Cancer Vaccination as a Promising New Treatment Against Tumors
Shelby Bradford, PhD | Mar 15, 2024 | 10+ min read
Vaccination has beaten back infections for more than a century. Now, it may be the next big step in battling cancer.
A bat flying in a dark cave
Turning on the Bat Signal
Hannah Thomasy, PhD | Mar 15, 2024 | 10+ min read
Scientists around the world investigate how bat immune systems cope with viral attacks and how this information could be used to keep humans safe.
Gene Therapy
The Scientist Staff | Aug 30, 1998 | 3 min read
Inder Verma L. Naldini, U. Blomer, P. Gallay, D. Ory, R. Mulligan, F.H. Gage, I.M. Verma, D. Trono, "In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector," Science, 272:263-7, 1996. (Cited in more than 185 papers since publication) Comments by Inder M. Verma, American Cancer Society professor of molecular biology at the Salk Institute for Biological Studies, La Jolla, Calif. In the world of gene therapy, there's a fine line between friend and foe. HIV at
A person moving the hands of a vintage clock backwards.
Synthetic Circuits Reveal the Key to Rewinding the Cellular Clock
Charlene Lancaster, PhD | Mar 12, 2024 | 4 min read
Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells.
immune cells t cell natural kill cell cardiac stem cell ipsc
Gene Editing Makes Cells Evade Immune Attack In Vitro
Emma Yasinski | Dec 12, 2019 | 3 min read
To advance the possibility of off-the-shelf cardiac cell therapies, scientists devise an engineered cardiac stem cell that avoids stimulating a detrimental immune attack.

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