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image: New Insights to Improve CAR T Cells’ Safety

New Insights to Improve CAR T Cells’ Safety

By Vicki Brower | June 5, 2018

Drugs approved to treat rheumatoid arthritis block cytokines, the molecules responsible for severe side effects from the immunotherapy, and reduce symptoms in mice.

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image: A T-Cell Tweak Combats Advanced Breast Cancer

A T-Cell Tweak Combats Advanced Breast Cancer

By Ashley Yeager | June 5, 2018

The immunotherapy eliminated a woman’s metastatic lesions and kept her disease-free for two years.

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Sequencing of a single gene can spot patients with a dangerous form of mycosis fungoides better than other prognostic tests.  

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image: New Ovarian Cancer Vaccine Shows Promise

New Ovarian Cancer Vaccine Shows Promise

By Catherine Offord | April 12, 2018

A preliminary clinical trial finds that the personalized therapy improves survival rates and has no severe side-effects.

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Mice treated with an immunostimulant had better outcomes when researchers blocked the expression of TNFR2, a compound that helps tumors evade immune attack.

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image: Antiviral Immunotherapy Comes of Age

Antiviral Immunotherapy Comes of Age

By Lucas Laursen | December 4, 2017

T-cell therapies are not just for cancer. Researchers are also advancing immunotherapy methods to protect bone marrow transplant patients from viral infections. 

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A team has engineered two stem cell lines into “synthetic T cells” that destroy breast cancer cells in vitro. 

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image: FDA Approves Second CAR T-Cell Therapy

FDA Approves Second CAR T-Cell Therapy

By Ashley P. Taylor | October 19, 2017

The therapy, produced by Kite Pharma and owned by Gilead Sciences, is approved for use against some types of large B-cell lymphomas. 

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image: Compound Found in Red Wine Boosts Immune Cell Function

Compound Found in Red Wine Boosts Immune Cell Function

By Catherine Offord | October 17, 2017

At low doses, resveratrol enhanced human T-cell activity in vitro, while at high doses it interfered with cell signaling. 

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image: The Ever-Expanding T-Cell World: A Primer

The Ever-Expanding T-Cell World: A Primer

By Ashley P. Taylor | August 7, 2017

Researchers continue to identify new T-cell subtypes—and devise ways to use them to fight cancer. The Scientist attempts to catalog them all.

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