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image: Alcohol Damages Mouse DNA

Alcohol Damages Mouse DNA

By Jef Akst | January 3, 2018

A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not repaired.

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The genome of an infant who lived in Alaska thousands of years ago represents a previously unknown group of humans called Ancient Beringians, who share a common lineage with other Native Americans. 

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image: Child Receives Transgenic Skin

Child Receives Transgenic Skin

By Ruth Williams | January 1, 2018

A combination gene-and-cell therapy has given a boy with a grievous skin disease a new lease on life, and resolved a dermatology debate to boot.

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image: Annina Schmid Dissects Nerve Disorders

Annina Schmid Dissects Nerve Disorders

By Catherine Offord | January 1, 2018

A background in physiotherapy helps the Oxford-based researcher mix basic science with clinical work to better understand pain stemming from nerve compression.

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image: Contributors

Contributors

By Jef Akst and Katarina Zimmer | January 1, 2018

Meet some of the people featured in the January 2018 issue of The Scientist.

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image: David Julius Probes the Molecular Mechanics of Pain

David Julius Probes the Molecular Mechanics of Pain

By Anna Azvolinsky | January 1, 2018

For nearly 30 years, the UC San Francisco researcher has delved into unexplored corners of the nervous system.

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image: Distinct Regions Drive Responses to Anxiety, Fear

Distinct Regions Drive Responses to Anxiety, Fear

By Catherine Offord | January 1, 2018

Researchers map brain activity associated with a person’s anticipation of or direct confrontation with danger.

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image: Glial Ties to Persistent Pain

Glial Ties to Persistent Pain

By Mark R. Hutchinson | January 1, 2018

Immune-like cells in the central nervous system are now recognized as key participants in the creation and maintenance of persistent pain.

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image: Infographic: A Painful Pathway

Infographic: A Painful Pathway

By Catherine Offord | January 1, 2018

Since the mid-2000s, the voltage-gated sodium channel NaV1.7 has emerged as a promising target for a new class of analgesics.

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image: Infographic: Anticipation Versus Confrontation

Infographic: Anticipation Versus Confrontation

By Catherine Offord | January 1, 2018

The brain is activated differently when it’s contemplating, rather than directly facing, a threat.

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